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Aging Increases Susceptibility to High Fat Diet-Induced Metabolic Syndrome in C57BL6 Mice: Improvement in Glycemic and Lipid Profile after Antioxidant Therapy
Joint Authors
Rabelo, Luíza A.
Nunes-Souza, Valéria
Smaniotto, Salete
César-Gomes, Cheila Juliana
Guedes, Glaucevane da S.
Fonseca, Lucas José S. da
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-18
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Nonalcoholic fatty liver disease (NAFLD) has been considered a novel component of the metabolic syndrome (MetS), with the oxidative stress participating in its progression.
This study aimed to evaluate the metabolic profile in young and old mice with MetS, and the effects of apocynin and tempol on glycemic and lipid parameters.
Young and old C57BL/6 mice with high fat diet- (HFD-) induced MetS received apocynin and tempol 50 mg·kg−1/day in their drinking water for 10 weeks.
After HFD, the young group showed elevated fasting glucose, worsened lipid profile in plasma, steatosis, and hepatic lipid peroxidation.
Nevertheless, the old group presented significant increase in fasting insulin levels, insulin resistance, plasma and hepatic lipid peroxidation, and pronounced steatosis.
The hepatic superoxide dismutase and catalase activity did not differ between the groups.
Tempol and apocynin seemed to prevent hepatic lipid deposition in both groups.
Furthermore, apocynin improved glucose tolerance and insulin sensitivity in old mice.
In summary, old mice are more susceptible to HFD-induced metabolic changes than their young counterparts.
Also, the antioxidant therapy improved insulin sensitivity and glucose tolerance, and in addition, apocynin seemed to prevent the HFD-induced hepatic fat deposition, suggesting an important role of oxidative stress in the induction of NAFLD.
American Psychological Association (APA)
Nunes-Souza, Valéria& César-Gomes, Cheila Juliana& Fonseca, Lucas José S. da& Guedes, Glaucevane da S.& Smaniotto, Salete& Rabelo, Luíza A.. 2016. Aging Increases Susceptibility to High Fat Diet-Induced Metabolic Syndrome in C57BL6 Mice: Improvement in Glycemic and Lipid Profile after Antioxidant Therapy. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1113673
Modern Language Association (MLA)
Nunes-Souza, Valéria…[et al.]. Aging Increases Susceptibility to High Fat Diet-Induced Metabolic Syndrome in C57BL6 Mice: Improvement in Glycemic and Lipid Profile after Antioxidant Therapy. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-17.
https://search.emarefa.net/detail/BIM-1113673
American Medical Association (AMA)
Nunes-Souza, Valéria& César-Gomes, Cheila Juliana& Fonseca, Lucas José S. da& Guedes, Glaucevane da S.& Smaniotto, Salete& Rabelo, Luíza A.. Aging Increases Susceptibility to High Fat Diet-Induced Metabolic Syndrome in C57BL6 Mice: Improvement in Glycemic and Lipid Profile after Antioxidant Therapy. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1113673
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113673