Estrogen Replacement Reduces Oxidative Stress in the Rostral Ventrolateral Medulla of Ovariectomized Rats
Joint Authors
Hao, Fan
Gu, Ying
Tan, Xing
Deng, Yu
Wu, Zhao-Tang
Xu, Ming-Juan
Wang, Wei-Zhong
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Cardiovascular disease prevalence rises rapidly after menopause, which is believed to be derived from the loss of estrogen.
It is reported that sympathetic tone is increased in postmenopause.
The high level of oxidative stress in the rostral ventrolateral medulla (RVLM) contributes to increased sympathetic outflow.
The focus of this study was to determine if estrogen replacement reduces oxidative stress in the RVLM and sympathetic outflow in the ovariectomized (OVX) rats.
The data of this study showed that OVX rat increased oxidative stress in the RVLM and sympathetic tone; estrogen replacement improved cardiovascular functions but also reduced the level of oxidative stress in the RVLM.
These findings suggest that estrogen replacement decreases blood pressure and sympathoexcitation in the OVX rats, which may be associated with suppression in oxidative stress in the RVLM through downregulation of protein expression of NADPHase (NOX4) and upregulation of protein expression of SOD1.
The data from this study is beneficial for our understanding of the mechanism of estrogen exerting cardiovascular protective effects on postmenopause.
American Psychological Association (APA)
Hao, Fan& Gu, Ying& Tan, Xing& Deng, Yu& Wu, Zhao-Tang& Xu, Ming-Juan…[et al.]. 2015. Estrogen Replacement Reduces Oxidative Stress in the Rostral Ventrolateral Medulla of Ovariectomized Rats. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1113687
Modern Language Association (MLA)
Hao, Fan…[et al.]. Estrogen Replacement Reduces Oxidative Stress in the Rostral Ventrolateral Medulla of Ovariectomized Rats. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1113687
American Medical Association (AMA)
Hao, Fan& Gu, Ying& Tan, Xing& Deng, Yu& Wu, Zhao-Tang& Xu, Ming-Juan…[et al.]. Estrogen Replacement Reduces Oxidative Stress in the Rostral Ventrolateral Medulla of Ovariectomized Rats. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1113687
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113687