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Markers of Antioxidant Defense in Patients with Type 2 Diabetes
Joint Authors
Fedak, Danuta
Malecki, Maciej T.
Gawlik, K.
Naskalski, J. W.
Pawlica-Gosiewska, D.
Grudzień, U.
Solnica, B.
Dumnicka, Paulina
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-10
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Aims.
Diabetes is considered a state of increased oxidative stress.
This study evaluates blood concentrations of selected markers of antioxidant defense in patients with type 2 diabetes.
Methods.
The study included 80 type 2 diabetes patients and 79 apparently healthy controls.
Measured markers included ferric reducing ability of plasma (FRAP), reduced glutathione (GSH), glutathione peroxidase (GPx), glutathione reductase (GR), γ-glutamyltransferase (GGT) and uric acid serum, and plasma and/or hemolysate levels.
Results.
FRAP, uric acid, CRP, and GGT levels were significantly higher in patients with diabetes.
Plasma and hemolysate GR was significantly higher whereas GPx activity was significantly lower in patients with diabetes.
There were no significant differences in antioxidant defense markers between patients with and without chronic diabetes complications.
Fasting serum glucose correlated with plasma GPx, plasma and hemolysate GR, FRAP, and serum GGT, and HbA1c correlated with serum GGT.
Only FRAP and serum uric acid were significantly higher in obese (BMI>30 kg/m2) patients with diabetes than in nonobese patients.
Conclusions.
Some components of antioxidant defense such as GR, uric acid, and GGT are increased in patients with type 2 diabetes.
However, the whole system cannot compensate for an enhanced production of ROS as reflected by the trend toward decreased erythrocytes GSH.
American Psychological Association (APA)
Gawlik, K.& Naskalski, J. W.& Fedak, Danuta& Pawlica-Gosiewska, D.& Grudzień, U.& Dumnicka, Paulina…[et al.]. 2015. Markers of Antioxidant Defense in Patients with Type 2 Diabetes. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1113693
Modern Language Association (MLA)
Gawlik, K.…[et al.]. Markers of Antioxidant Defense in Patients with Type 2 Diabetes. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1113693
American Medical Association (AMA)
Gawlik, K.& Naskalski, J. W.& Fedak, Danuta& Pawlica-Gosiewska, D.& Grudzień, U.& Dumnicka, Paulina…[et al.]. Markers of Antioxidant Defense in Patients with Type 2 Diabetes. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1113693
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113693