Integrated Approaches to Drug Discovery for Oxidative Stress-Related Retinal Diseases
Joint Authors
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-07
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Excessive oxidative stress induces dysregulation of functional networks in the retina, resulting in retinal diseases such as glaucoma, age-related macular degeneration, and diabetic retinopathy.
Although various therapies have been developed to reduce oxidative stress in retinal diseases, most have failed to show efficacy in clinical trials.
This may be due to oversimplification of target selection for such a complex network as oxidative stress.
Recent advances in high-throughput technologies have facilitated the collection of multilevel omics data, which has driven growth in public databases and in the development of bioinformatics tools.
Integration of the knowledge gained from omics databases can be used to generate disease-related biological networks and to identify potential therapeutic targets within the networks.
Here, we provide an overview of integrative approaches in the drug discovery process and provide simple examples of how the approaches can be exploited to identify oxidative stress-related targets for retinal diseases.
American Psychological Association (APA)
Nishimura, Yuhei& Hara, Hideaki. 2016. Integrated Approaches to Drug Discovery for Oxidative Stress-Related Retinal Diseases. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113698
Modern Language Association (MLA)
Nishimura, Yuhei& Hara, Hideaki. Integrated Approaches to Drug Discovery for Oxidative Stress-Related Retinal Diseases. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1113698
American Medical Association (AMA)
Nishimura, Yuhei& Hara, Hideaki. Integrated Approaches to Drug Discovery for Oxidative Stress-Related Retinal Diseases. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113698
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113698