Therapeutic Strategies for Oxidative Stress-Related Cardiovascular Diseases: Removal of Excess Reactive Oxygen Species in Adult Stem Cells

Joint Authors

Kim, Hyunyun
Yun, Jisoo
Kwon, Sang-Mo

Source

Oxidative Medicine and Cellular Longevity

Issue

Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2016-09-07

Country of Publication

Egypt

No. of Pages

11

Main Subjects

Biology

Abstract EN

Accumulating evidence indicates that acute and chronic uncontrolled overproduction of oxidative stress-related factors including reactive oxygen species (ROS) causes cardiovascular diseases (CVDs), atherosclerosis, and diabetes.

Moreover ROS mediate various signaling pathways underlying vascular inflammation in ischemic tissues.

With respect to stem cell-based therapy, several studies clearly indicate that modulating antioxidant production at cellular levels enhances stem/progenitor cell functionalities, including proliferation, long-term survival in ischemic tissues, and complete differentiation of transplanted cells into mature vascular cells.

Recently emerging therapeutic strategies involving adult stem cells, including endothelial progenitor cells (EPCs), for treating ischemic CVDs have highlighted the need to control intracellular ROS production, because it critically affects the replicative senescence of ex vivo expanded therapeutic cells.

Better understanding of the complexity of cellular ROS in stem cell biology might improve cell survival in ischemic tissues and enhance the regenerative potentials of transplanted stem/progenitor cells.

In this review, we will discuss the nature and sources of ROS, drug-based therapeutic strategies for scavenging ROS, and EPC based therapeutic strategies for treating oxidative stress-related CVDs.

Furthermore, we will discuss whether primed EPCs pretreated with natural ROS-scavenging compounds are crucial and promising therapeutic strategies for vascular repair.

American Psychological Association (APA)

Kim, Hyunyun& Yun, Jisoo& Kwon, Sang-Mo. 2016. Therapeutic Strategies for Oxidative Stress-Related Cardiovascular Diseases: Removal of Excess Reactive Oxygen Species in Adult Stem Cells. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113708

Modern Language Association (MLA)

Kim, Hyunyun…[et al.]. Therapeutic Strategies for Oxidative Stress-Related Cardiovascular Diseases: Removal of Excess Reactive Oxygen Species in Adult Stem Cells. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1113708

American Medical Association (AMA)

Kim, Hyunyun& Yun, Jisoo& Kwon, Sang-Mo. Therapeutic Strategies for Oxidative Stress-Related Cardiovascular Diseases: Removal of Excess Reactive Oxygen Species in Adult Stem Cells. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113708

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1113708