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Nigella sativa Relieves the Altered Insulin Receptor Signaling in Streptozotocin-Induced Diabetic Rats Fed with a High-Fat Diet
Joint Authors
Ghareeb, Doaa A.
Balbaa, Mahmoud
El-Zeftawy, Marwa
Taha, Nabil
Mandour, Abdel Wahab
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-04
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
The black cumin (Nigella sativa) “NS” or the black seeds have many pharmacological activities such as antioxidant, anticarcinogenic, antihypertensive, and antidiabetic properties.
In this work, streptozotocin-induced diabetic rats fed with a high-fat diet were treated daily with NS oil (NSO) in order to study the effect on the blood glucose, lipid profile, oxidative stress parameters, and the gene expression of some insulin receptor-induced signaling molecules.
This treatment was combined also with some drugs (metformin and glimepiride) and the insulin receptor inhibitor I-OMe-AG538.
The administration of NSO significantly induced the gene expression of insulin receptor compared to rats that did not receive NSO.
Also, it upregulated the expression of insulin-like growth factor-1 and phosphoinositide-3 kinase, whereas the expression of ADAM-17 was downregulated.
The expression of ADAM-17 is corroborated by the analysis of TIMP-3 content.
In addition, the NSO significantly reduced blood glucose level, components of the lipid profile, oxidative stress parameters, serum insulin/insulin receptor ratio, and the tumor necrosis factor-α, confirming that NSO has an antidiabetic activity.
Thus, the daily NSO treatment in our rat model indicates that NSO has a potential in the management of diabetes as well as improvement of insulin-induced signaling.
American Psychological Association (APA)
Balbaa, Mahmoud& El-Zeftawy, Marwa& Ghareeb, Doaa A.& Taha, Nabil& Mandour, Abdel Wahab. 2016. Nigella sativa Relieves the Altered Insulin Receptor Signaling in Streptozotocin-Induced Diabetic Rats Fed with a High-Fat Diet. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1113709
Modern Language Association (MLA)
Balbaa, Mahmoud…[et al.]. Nigella sativa Relieves the Altered Insulin Receptor Signaling in Streptozotocin-Induced Diabetic Rats Fed with a High-Fat Diet. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-16.
https://search.emarefa.net/detail/BIM-1113709
American Medical Association (AMA)
Balbaa, Mahmoud& El-Zeftawy, Marwa& Ghareeb, Doaa A.& Taha, Nabil& Mandour, Abdel Wahab. Nigella sativa Relieves the Altered Insulin Receptor Signaling in Streptozotocin-Induced Diabetic Rats Fed with a High-Fat Diet. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1113709
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113709