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The Impact of Lipoprotein-Associated Oxidative Stress on Cell-Specific Microvesicle Release in Patients with Familial Hypercholesterolemia
Joint Authors
Nielsen, M. H.
Irvine, H.
Vedel, S.
Raungaard, B.
Beck-Nielsen, H.
Handberg, A.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
Microvesicles (MVs) are small cell-derived particles shed upon activation.
Familial hypercholesterolemia (FH) particularly when associated with Achilles tendon xanthomas (ATX) predisposes to atherosclerosis, possibly through oxLDL-C interaction with the CD36 receptor.
To investigate the hypothesis that MVs derived from cells involved in atherosclerosis are increased in FH and that CD36 expressing MVs (CD36+ MVs) may be markers of oxLDL-C-induced cell activation, cell-specific MVs were measured in FH patients with and without ATX and their association with atherogenic lipid profile was studied.
Approach and Results.
Thirty FH patients with and without ATX and twenty-three controls were included.
Plasma concentrations of MVs and CD36+ MVs derived from platelets (PMVs), erythrocytes (ErytMVs), monocytes (MMVs), and endothelial cells (EMVs), as well as tissue factor-positive cells (TF+ MVs), were measured by flow cytometry.
Total MVs, MMVs, EMVs, ErytMVs, and TF+ MVs were significantly increased in FH patients, compared to controls.
CD36+ MVs derived from endothelial cells and monocytes were significantly higher in FH patients and oxLDL-C predicted all the investigated cell-specific CD36+ MVs in FH patients with ATX.
Conclusions.
MVs derived from cells involved in atherosclerosis were increased in FH and may contribute to elevated atherothrombosis risk.
The increased cell-specific CD36+ MVs observed in FH may represent markers of oxLDL-C-induced cell activation.
American Psychological Association (APA)
Nielsen, M. H.& Irvine, H.& Vedel, S.& Raungaard, B.& Beck-Nielsen, H.& Handberg, A.. 2016. The Impact of Lipoprotein-Associated Oxidative Stress on Cell-Specific Microvesicle Release in Patients with Familial Hypercholesterolemia. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1113712
Modern Language Association (MLA)
Nielsen, M. H.…[et al.]. The Impact of Lipoprotein-Associated Oxidative Stress on Cell-Specific Microvesicle Release in Patients with Familial Hypercholesterolemia. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1113712
American Medical Association (AMA)
Nielsen, M. H.& Irvine, H.& Vedel, S.& Raungaard, B.& Beck-Nielsen, H.& Handberg, A.. The Impact of Lipoprotein-Associated Oxidative Stress on Cell-Specific Microvesicle Release in Patients with Familial Hypercholesterolemia. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1113712
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113712