Allium cepa Extract and Quercetin Protect Neuronal Cells from Oxidative Stress via PKC-ε InactivationERK12 Activation
Joint Authors
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-07
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Oxidative stress plays an important role in the pathophysiology of various neurologic disorders.
Allium cepa extract (ACE) and their main flavonoid component quercetin (QCT) possess antioxidant activities and protect neurons from oxidative stress.
We investigated the underlying molecular mechanisms, particularly those linked to the antioxidant effects of the ACE.
Primary cortical neuronal cells derived from mouse embryos were preincubated with ACE or QCT for 30 min and exposed to L-buthionine sulfoximine for 4~24 h.
We found that ACE and QCT significantly decreased neuronal death and the ROS increase induced by L-buthionine-S, R-sulfoximine (BSO) in a concentration-dependent manner.
Furthermore, ACE and QCT activated extracellular signal-regulated kinase 1/2 (ERK1/2), leading to downregulation of protein kinase C-ε (PKC-ε) in BSO-stimulated neuronal cells.
In addition, ACE and QCT decreased the phosphorylated levels of p38 mitogen-activated protein kinase.
Our results provide new insight into the protective mechanism of ACE and QCT against oxidative stress in neuronal cells.
The results suggest that the inactivation of PKC-ε induced by phosphorylating ERK1/2 is responsible for the neuroprotective effect of ACE and QCT against BSO-induced oxidative stress.
American Psychological Association (APA)
Lee, Bo Kyung& Jung, Yi-Sook. 2016. Allium cepa Extract and Quercetin Protect Neuronal Cells from Oxidative Stress via PKC-ε InactivationERK12 Activation. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113713
Modern Language Association (MLA)
Lee, Bo Kyung& Jung, Yi-Sook. Allium cepa Extract and Quercetin Protect Neuronal Cells from Oxidative Stress via PKC-ε InactivationERK12 Activation. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1113713
American Medical Association (AMA)
Lee, Bo Kyung& Jung, Yi-Sook. Allium cepa Extract and Quercetin Protect Neuronal Cells from Oxidative Stress via PKC-ε InactivationERK12 Activation. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113713
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113713