Effects of Polyphenol, Measured by a Biomarker of Total Polyphenols in Urine, on Cardiovascular Risk Factors After a Long-Term Follow-Up in the PREDIMED Study
Joint Authors
Guo, Xiaohui
Tresserra-Rimbau, Anna
Estruch, Ramón
Martínez-González, Miguel A.
Medina-Remón, Alexander
Castañer, Olga
Corella, Dolores
Lamuela-Raventós, Rosa M.
Salas-Salvadó, Jordi
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-04
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Several epidemiological studies have shown an inverse association between the consumption of polyphenol-rich foods and risk of cardiovascular diseases.
However, accuracy and reliability of these studies may be increased using urinary total polyphenol excretion (TPE) as a biomarker for total polyphenol intake.
Our aim was to assess if antioxidant activity, measured by a Folin-Ciocalteu assay in urine, is correlated with an improvement in cardiovascular risk factors (blood pressure and serum glucose, cholesterol, HDL-cholesterol, LDL-cholesterol, and triglyceride concentrations) in an elderly population at high risk.
A longitudinal study was performed with 573 participants (aged 67.3 ± 5.9) from the PREDIMED study (ISRCTN35739639).
We used Folin-Ciocalteu method to determine TPE in urine samples, assisting with solid phase extraction.
Participants were categorized into three groups according to changes in TPE.
Multiple linear regression models were used to assess relationships between TPE and clinical cardiovascular risk factors, adjusting for potential confounders.
After a 5-year follow-up, significant inverse correlations were observed between changes in TPE and plasma triglyceride concentration ( β = - 8.563 ; P = 0.007 ), glucose concentration ( β = - 4.164 ; P = 0.036 ), and diastolic blood pressure ( β = - 1.316 ; P = 0.013 ).
Our results suggest that the consumption of more polyphenols, measured as TPE in urine, could exert a protective effect against some cardiovascular risk factors.
American Psychological Association (APA)
Guo, Xiaohui& Tresserra-Rimbau, Anna& Estruch, Ramón& Martínez-González, Miguel A.& Medina-Remón, Alexander& Castañer, Olga…[et al.]. 2016. Effects of Polyphenol, Measured by a Biomarker of Total Polyphenols in Urine, on Cardiovascular Risk Factors After a Long-Term Follow-Up in the PREDIMED Study. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113722
Modern Language Association (MLA)
Guo, Xiaohui…[et al.]. Effects of Polyphenol, Measured by a Biomarker of Total Polyphenols in Urine, on Cardiovascular Risk Factors After a Long-Term Follow-Up in the PREDIMED Study. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1113722
American Medical Association (AMA)
Guo, Xiaohui& Tresserra-Rimbau, Anna& Estruch, Ramón& Martínez-González, Miguel A.& Medina-Remón, Alexander& Castañer, Olga…[et al.]. Effects of Polyphenol, Measured by a Biomarker of Total Polyphenols in Urine, on Cardiovascular Risk Factors After a Long-Term Follow-Up in the PREDIMED Study. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113722
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113722