The Injury and Therapy of Reactive Oxygen Species in Intracerebral Hemorrhage Looking at Mitochondria
Joint Authors
Feng, Hua
Qu, Jie
Chen, Weixiang
Hu, Rong
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Intracerebral hemorrhage is an emerging major health problem often resulting in death or disability.
Reactive oxygen species (ROS) have been identified as one of the major damaging factors in ischemic stroke.
However, there is less discussion about ROS in hemorrhage stroke.
Metabolic products of hemoglobin, excitatory amino acids, and inflammatory cells are all sources of ROS, and ROS harm the central nervous system through cell death and structural damage, especially disruption of the blood-brain barrier.
We have considered the antioxidant system of the CNS itself and the drugs aiming to decrease ROS after ICH, and we find that mitochondria are key players in all of these aspects.
Moreover, when the mitochondrial permeability transition pore opens, ROS-induced ROS release, which leads to extensive liberation of ROS and mitochondrial failure, occurs.
Therefore, the mitochondrion may be a significant target for elucidating the problem of ROS in ICH; however, additional experimental support is required.
American Psychological Association (APA)
Qu, Jie& Chen, Weixiang& Hu, Rong& Feng, Hua. 2016. The Injury and Therapy of Reactive Oxygen Species in Intracerebral Hemorrhage Looking at Mitochondria. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113728
Modern Language Association (MLA)
Qu, Jie…[et al.]. The Injury and Therapy of Reactive Oxygen Species in Intracerebral Hemorrhage Looking at Mitochondria. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1113728
American Medical Association (AMA)
Qu, Jie& Chen, Weixiang& Hu, Rong& Feng, Hua. The Injury and Therapy of Reactive Oxygen Species in Intracerebral Hemorrhage Looking at Mitochondria. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113728
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113728