(Z)-5-(2,4-Dihydroxybenzylidene)thiazolidine-2,4-dione Prevents UVB-Induced Melanogenesis and Wrinkle Formation through Suppressing Oxidative Stress in HRM-2 Hairless Mice
Joint Authors
Lee, Bonggi
Moon, Kyoung Mi
Kim, Seong Jin
Kim, So Hee
Kim, Dae Hyun
An, Hye Jin
Jeong, Ji Won
Kim, Ye Ra
Son, Sujin
Kim, Min Jo
Chung, Ki Wung
Lee, Eun Kyeong
Chun, Pusoon
Kim, Min-Sun
Moon, Hyung Ryong
Young Chung, Hae
Ha, Young Mi
Moh, Sang Hyun
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Uncontrolled melanogenesis and wrinkle formation are an indication of photoaging.
Our previous studies demonstrated that (Z)-5-(2,4-dihydroxybenzylidene)thiazolidine-2,4-dione (MHY498) inhibited tyrosinase activity and melanogenesis in vitro.
Objective.
To examine in vivo effects of MHY498 as an antiaging compound on UVB-induced melanogenesis and wrinkle formation, we topically applied MHY498 on dorsal skin of HRM-2 hairless mice.
Methods.
Using histological analysis, we evaluated effects of MHY498 on melanogenesis and wrinkle formation after UVB exposure.
In addition, related molecular signaling pathways were examined using western blotting, fluorometric assay, and enzyme-linked immunosorbent assay.
Results.
MHY498 suppressed UVB-induced melanogenesis by inhibiting phosphorylation of CREB and translocation of MITF protein into the nucleus, which are key factors for tyrosinase expression.
Consistently, tyrosinase protein levels were notably reduced in the dorsal skin of the hairless mice by MHY498 treatment.
Furthermore, MHY498 inhibited UVB-induced wrinkle formation and collagen fiber destruction by increasing type 1 procollagen concentration and decreasing protein expression levels of MMPs, which play an essential role in collagen fiber degradation.
As a mechanism, MHY498 notably ameliorated UVB-induced oxidative stress and NF-κB activation in the dermal skin of the hairless mice.
Conclusion.
Our study suggests that MHY498 can be used as a therapeutic or cosmetic agent for preventing uncontrolled melanogenesis and wrinkle formation.
American Psychological Association (APA)
Lee, Bonggi& Moon, Kyoung Mi& Kim, Seong Jin& Kim, So Hee& Kim, Dae Hyun& An, Hye Jin…[et al.]. 2016. (Z)-5-(2,4-Dihydroxybenzylidene)thiazolidine-2,4-dione Prevents UVB-Induced Melanogenesis and Wrinkle Formation through Suppressing Oxidative Stress in HRM-2 Hairless Mice. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113741
Modern Language Association (MLA)
Lee, Bonggi…[et al.]. (Z)-5-(2,4-Dihydroxybenzylidene)thiazolidine-2,4-dione Prevents UVB-Induced Melanogenesis and Wrinkle Formation through Suppressing Oxidative Stress in HRM-2 Hairless Mice. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1113741
American Medical Association (AMA)
Lee, Bonggi& Moon, Kyoung Mi& Kim, Seong Jin& Kim, So Hee& Kim, Dae Hyun& An, Hye Jin…[et al.]. (Z)-5-(2,4-Dihydroxybenzylidene)thiazolidine-2,4-dione Prevents UVB-Induced Melanogenesis and Wrinkle Formation through Suppressing Oxidative Stress in HRM-2 Hairless Mice. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113741
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113741