Epistatic Interaction of CYP1A1 and COMT Polymorphisms in Cervical Cancer
Joint Authors
Matos, Andreia
Pereira da Silva, Alda
Clara Bicho, Maria
Alho, I.
Castelão, Cindy
Bicho, Manuel
Osório, Teresa
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-21
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
There is a clear association between the excessive and cumulative exposure to estrogens and the development of cancer in hormone-sensitive tissues, such as the cervix.
We studied the association of CYP1A1 M1 (rs4646903) and COMT (rs4680) polymorphisms in 130 cervical cancer cases (c-cancer) and 179 controls.
The CYP1A1 TT genotype was associated with a lower risk for c-cancer (OR = 0.39, p=0.002).
The allele C of CYP1A1 was a risk for c-cancer (OR = 2.29, p=0.002).
Women with COMT LL genotype had a higher risk of developing c-cancer (OR = 4.83, p<0.001).
For the interaction of the CYP1A1&COMT, we observed that TC&HL genotypes had a greater risk for c-cancer (OR = 6.07, p=0.006) and TT&HL genotypes had a protection effect (OR = 0.24, p<0.001).
The CYP1A1 TT and COMT LL genotypes had higher estradiol levels in c-cancer (p<0.001 and p=0.037, resp.).
C-cancer is associated with less production of 2-methoxy-estradiol resultant of functional polymorphisms of CYP1A1 and COMT, separately.
CYP1A1 and COMT work in a metabolic sequence and their interaction could lead to an alternative pathway of estrogen metabolism with production of 16-OH-estrone that is more proliferative.
American Psychological Association (APA)
Matos, Andreia& Castelão, Cindy& Pereira da Silva, Alda& Alho, I.& Bicho, Manuel& Osório, Teresa…[et al.]. 2015. Epistatic Interaction of CYP1A1 and COMT Polymorphisms in Cervical Cancer. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1113744
Modern Language Association (MLA)
Matos, Andreia…[et al.]. Epistatic Interaction of CYP1A1 and COMT Polymorphisms in Cervical Cancer. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1113744
American Medical Association (AMA)
Matos, Andreia& Castelão, Cindy& Pereira da Silva, Alda& Alho, I.& Bicho, Manuel& Osório, Teresa…[et al.]. Epistatic Interaction of CYP1A1 and COMT Polymorphisms in Cervical Cancer. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1113744
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113744