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The Reactive Oxygen Species in Macrophage Polarization: Reflecting Its Dual Role in Progression and Treatment of Human Diseases
Joint Authors
Wang, Ning
Tan, Hor Yue
Hong, Ming
Li, Sha
Wang, Xuanbin
Feng, Yibin
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-06
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
High heterogeneity of macrophage is associated with its functions in polarization to different functional phenotypes depending on environmental cues.
Macrophages remain in balanced state in healthy subject and thus macrophage polarization may be crucial in determining the tissue fate.
The two distinct populations, classically M1 and alternatively M2 activated, representing the opposing ends of the full activation spectrum, have been extensively studied for their associations with several disease progressions.
Accumulating evidences have postulated that the redox signalling has implication in macrophage polarization and the key roles of M1 and M2 macrophages in tissue environment have provided the clue for the reasons of ROS abundance in certain phenotype.
M1 macrophages majorly clearing the pathogens and ROS may be crucial for the regulation of M1 phenotype, whereas M2 macrophages resolve inflammation which favours oxidative metabolism.
Therefore how ROS play its role in maintaining the homeostatic functions of macrophage and in particular macrophage polarization will be reviewed here.
We also review the biology of macrophage polarization and the disturbance of M1/M2 balance in human diseases.
The potential therapeutic opportunities targeting ROS will also be discussed, hoping to provide insights for development of target-specific delivery system or immunomodulatory antioxidant for the treatment of ROS-related diseases.
American Psychological Association (APA)
Tan, Hor Yue& Wang, Ning& Li, Sha& Hong, Ming& Wang, Xuanbin& Feng, Yibin. 2016. The Reactive Oxygen Species in Macrophage Polarization: Reflecting Its Dual Role in Progression and Treatment of Human Diseases. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1113745
Modern Language Association (MLA)
Tan, Hor Yue…[et al.]. The Reactive Oxygen Species in Macrophage Polarization: Reflecting Its Dual Role in Progression and Treatment of Human Diseases. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-16.
https://search.emarefa.net/detail/BIM-1113745
American Medical Association (AMA)
Tan, Hor Yue& Wang, Ning& Li, Sha& Hong, Ming& Wang, Xuanbin& Feng, Yibin. The Reactive Oxygen Species in Macrophage Polarization: Reflecting Its Dual Role in Progression and Treatment of Human Diseases. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1113745
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113745