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Hydrogen Sulfide Inhibits High-Salt Diet-Induced Renal Oxidative Stress and Kidney Injury in Dahl Rats
Joint Authors
Junbao, D.
Wang, Su-Xia
Huang, Yaqian
Chen, Siyao
Tang, Chaoshu
Huang, Pan
Shen, Zhizhou
Liu, Jia
Yu, Wen
Ren, Yali
Li, Xiaohui
Jin, Hongfang
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-28
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Background.
The study was designed to investigate if H2S could inhibit high-salt diet-induced renal excessive oxidative stress and kidney injury in Dahl rats.
Methods.
Male salt-sensitive Dahl and SD rats were used.
Blood pressure (BP), serum creatinine, urea, creatinine clearance rate, and 24-hour urine protein were measured.
Renal ultra- and microstructures were observed.
Collagen-I and -III contents the oxidants and antioxidants levels in renal tissue were detected.
Keap1/Nrf2 association and Keap1 s-sulfhydration were detected.
Results.
After 8 weeks of high-salt diet, BP was significantly increased, renal function and structure were impaired, and collagen deposition was abundant in renal tissues with increased renal MPO activity, H2O2, MDA, GSSG, and •OH contents, reduced renal T-AOC and GSH contents, CAT, GSH-PX and SOD activity, and SOD expressions in Dahl rats.
Furthermore, endogenous H2S in renal tissues was decreased in Dahl rats.
H2S donor, however, decreased BP, improved renal function and structure, and inhibited collagen excessive deposition in kidney, in association with increased antioxidative activity and reduced oxidative stress in renal tissues.
H2S activated Nrf2 by inducing Keap1 s-sulfhydration and subsequent Keap1/Nrf2 disassociation.
Conclusions.
H2S protected against high-salt diet-induced renal injury associated with enhanced antioxidant capacity and inhibited renal oxidative stress.
American Psychological Association (APA)
Huang, Pan& Shen, Zhizhou& Liu, Jia& Huang, Yaqian& Chen, Siyao& Yu, Wen…[et al.]. 2015. Hydrogen Sulfide Inhibits High-Salt Diet-Induced Renal Oxidative Stress and Kidney Injury in Dahl Rats. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1113746
Modern Language Association (MLA)
Huang, Pan…[et al.]. Hydrogen Sulfide Inhibits High-Salt Diet-Induced Renal Oxidative Stress and Kidney Injury in Dahl Rats. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-15.
https://search.emarefa.net/detail/BIM-1113746
American Medical Association (AMA)
Huang, Pan& Shen, Zhizhou& Liu, Jia& Huang, Yaqian& Chen, Siyao& Yu, Wen…[et al.]. Hydrogen Sulfide Inhibits High-Salt Diet-Induced Renal Oxidative Stress and Kidney Injury in Dahl Rats. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1113746
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113746