Biofunctional Activities of Equisetum ramosissimum Extract: Protective Effects against Oxidation, Melanoma, and Melanogenesis
Joint Authors
Ma, Dik-Lung
Wen, Zhi-Hong
Huang, Shu-Hung
Chiu, Chien-Chih
Leung, Chung-Hang
Li, Pin-Hui
Chiu, Yu-Pin
Shih, Chieh-Chih
Ibeto, Laura Kaodichi
Chang, Yaw-Nan
Wang, Hui-Min
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Equisetum ramosissimum, a genus of Equisetaceae, is a medicinal plant that can be separated into ethyl acetate (EA), dichloromethane (DM), n-hexane (Hex), methanol (MeOH), and water extracts.
EA extract was known to have potent antioxidative properties, reducing power, DPPH scavenging activity, and metal ion chelating activity.
This study compared these five extracts in terms of their inhibiting effects on three human malignant melanomas: A375, A375.S2, and A2058.
MTT assay presented the notion that both EA and DM extracts inhibited melanoma growth but did not affect the viabilities of normal dermal keratinocytes (HaCaT) or fibroblasts.
Western blot analyses showed that both EA and DM extracts induced overexpression of caspase proteins in all three melanomas.
To determine their roles in melanogenesis, this study analyzed their in vitro suppressive effects on mushroom tyrosinase.
All extracts except for water revealed moderate suppressive effects.
None of the extracts affected B16-F10 cells proliferation.
EA extract inhibited cellular melanin production whereas DM extract unexpectedly enhanced cellular pigmentation in B16-F10 cells.
Data for modulations of microphthalmia-associated transcription factor, tyrosinase, tyrosinase-related protein 1, and tyrosinase-related protein 2 showed that EA extract inhibited protein expression mentioned above whereas DM extract had the opposite effect.
Overall, the experiments indicated that the biofunctional activities of EA extract contained in food and cosmetics protect against oxidation, melanoma, and melanin production.
American Psychological Association (APA)
Li, Pin-Hui& Chiu, Yu-Pin& Shih, Chieh-Chih& Wen, Zhi-Hong& Ibeto, Laura Kaodichi& Huang, Shu-Hung…[et al.]. 2016. Biofunctional Activities of Equisetum ramosissimum Extract: Protective Effects against Oxidation, Melanoma, and Melanogenesis. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113750
Modern Language Association (MLA)
Li, Pin-Hui…[et al.]. Biofunctional Activities of Equisetum ramosissimum Extract: Protective Effects against Oxidation, Melanoma, and Melanogenesis. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1113750
American Medical Association (AMA)
Li, Pin-Hui& Chiu, Yu-Pin& Shih, Chieh-Chih& Wen, Zhi-Hong& Ibeto, Laura Kaodichi& Huang, Shu-Hung…[et al.]. Biofunctional Activities of Equisetum ramosissimum Extract: Protective Effects against Oxidation, Melanoma, and Melanogenesis. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113750
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113750