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Oxidative Stress Markers in Sputum
Author
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-14
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Although oxidative stress is thought to play a pivotal role in the pathogenesis of inflammatory airway diseases, its assessment in clinical practice remains elusive.
In recent years, it has been conceptualized that oxidative stress markers in sputum should be employed to monitor oxidative processes in patients with asthma, chronic obstructive pulmonary disease (COPD), or cystic fibrosis (CF).
In this review, the use of sputum-based oxidative markers was explored and potential clinical applications were considered.
Among lipid peroxidation-derived products, 8-isoprostane and malondialdehyde have been the most frequently investigated, while nitrosothiols and nitrotyrosine may serve as markers of nitrosative stress.
Several studies have showed higher levels of these products in patients with asthma, COPD, or CF compared to healthy subjects.
Marker concentrations could be further increased during exacerbations and decreased along with recovery of these diseases.
Measurement of oxidized guanine species and antioxidant enzymes in the sputum could be other approaches for assessing oxidative stress in pulmonary patients.
Collectively, even though there are promising findings in this field, further clinical studies using more established detection techniques are needed to clearly show the benefit of these measurements in the follow-up of patients with inflammatory airway diseases.
American Psychological Association (APA)
Antus, B.. 2016. Oxidative Stress Markers in Sputum. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1113755
Modern Language Association (MLA)
Antus, B.. Oxidative Stress Markers in Sputum. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1113755
American Medical Association (AMA)
Antus, B.. Oxidative Stress Markers in Sputum. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1113755
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113755