Effects of Oxidative Stress on Mesenchymal Stem Cell Biology
Joint Authors
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Mesenchymal stromal/stem cells (MSCs) are multipotent stem cells present in most fetal and adult tissues.
Ex vivo culture-expanded MSCs are being investigated for tissue repair and immune modulation, but their full clinical potential is far from realization.
Here we review the role of oxidative stress in MSC biology, as their longevity and functions are affected by oxidative stress.
In general, increased reactive oxygen species (ROS) inhibit MSC proliferation, increase senescence, enhance adipogenic but reduce osteogenic differentiation, and inhibit MSC immunomodulation.
Furthermore, aging, senescence, and oxidative stress reduce their ex vivo expansion, which is critical for their clinical applications.
Modulation of sirtuin expression and activity may represent a method to reduce oxidative stress in MSCs.
These findings have important implications in the clinical utility of MSCs for degenerative and immunological based conditions.
Further study of oxidative stress in MSCs is imperative in order to enhance MSC ex vivo expansion and in vivo engraftment, function, and longevity.
American Psychological Association (APA)
Denu, Ryan A.& Hematti, Peiman. 2016. Effects of Oxidative Stress on Mesenchymal Stem Cell Biology. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113761
Modern Language Association (MLA)
Denu, Ryan A.& Hematti, Peiman. Effects of Oxidative Stress on Mesenchymal Stem Cell Biology. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1113761
American Medical Association (AMA)
Denu, Ryan A.& Hematti, Peiman. Effects of Oxidative Stress on Mesenchymal Stem Cell Biology. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113761
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113761