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Gsk3 Signalling and Redox Status in Bipolar Disorder: Evidence from Lithium Efficacy
Joint Authors
Luca, Maria
Luca, Antonina
Calandra, Carmela
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-18
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Objective.
To discuss the link between glycogen synthase kinase-3 (GSK3) and the main biological alterations demonstrated in bipolar disorder (BD), with special attention to the redox status and the evidence supporting the efficacy of lithium (a GSK3 inhibitor) in the treatment of BD.
Methods.
A literature research on the discussed topics, using Pubmed and Google Scholar, has been conducted.
Moreover, a manual selection of interesting references from the identified articles has been performed.
Results.
The main biological alterations of BD, pertaining to inflammation, oxidative stress, membrane ion channels, and circadian system, seem to be intertwined.
The dysfunction of the GSK3 signalling pathway is involved in all the aforementioned “biological causes” of BD.
In a complex scenario, it can be seen as the common denominator linking them all.
Lithium inhibition of GSK3 could, at least in part, explain its positive effect on these biological dysfunctions and its superiority in terms of clinical efficacy.
Conclusions.
Deepening the knowledge on the molecular bases of BD is fundamental to identifying the biochemical pathways that must be targeted in order to provide patients with increasingly effective therapeutic tools against an invalidating disorder such as BD.
American Psychological Association (APA)
Luca, Antonina& Calandra, Carmela& Luca, Maria. 2016. Gsk3 Signalling and Redox Status in Bipolar Disorder: Evidence from Lithium Efficacy. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1113763
Modern Language Association (MLA)
Luca, Antonina…[et al.]. Gsk3 Signalling and Redox Status in Bipolar Disorder: Evidence from Lithium Efficacy. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1113763
American Medical Association (AMA)
Luca, Antonina& Calandra, Carmela& Luca, Maria. Gsk3 Signalling and Redox Status in Bipolar Disorder: Evidence from Lithium Efficacy. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1113763
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113763