Sirtuins and Cancer: Role in the Epithelial-Mesenchymal Transition
Joint Authors
Lauro, Davide
Guadagni, Fiorella
Palmirotta, Raffaele
Cives, Mauro
Della-Morte, David
Capuani, Barbara
Silvestris, Franco
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-09
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The human sirtuins (SIRT1–SIRT7) enzymes are a highly conserved family of NAD+-dependent histone deacetylases, which play a critical role in the regulation of a large number of metabolic pathways involved in stress response and aging.
Cancer is an age-associated disease, and sirtuins may have a considerable impact on a plethora of processes that regulate tumorigenesis.
In particular, growing evidence suggests that sirtuins may modulate epithelial plasticity by inducing transcriptional reprogramming leading to epithelial-mesenchymal transition (EMT), invasion, and metastases.
Though commonly regarded as EMT inducers, sirtuins may also suppress this process, and their functional properties seem to largely depend on the cellular context, stage of cancer development, tissue of origin, and microenvironment architecture.
Here, we review the role of sirtuins in cancer biology with particular emphasis on their role in EMT.
American Psychological Association (APA)
Palmirotta, Raffaele& Cives, Mauro& Della-Morte, David& Capuani, Barbara& Lauro, Davide& Guadagni, Fiorella…[et al.]. 2016. Sirtuins and Cancer: Role in the Epithelial-Mesenchymal Transition. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113764
Modern Language Association (MLA)
Palmirotta, Raffaele…[et al.]. Sirtuins and Cancer: Role in the Epithelial-Mesenchymal Transition. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1113764
American Medical Association (AMA)
Palmirotta, Raffaele& Cives, Mauro& Della-Morte, David& Capuani, Barbara& Lauro, Davide& Guadagni, Fiorella…[et al.]. Sirtuins and Cancer: Role in the Epithelial-Mesenchymal Transition. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113764
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113764