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Widening and Elaboration of Consecutive Research into Therapeutic Antioxidant Enzyme Derivatives
Author
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Undiminishing actuality of enzyme modification for therapeutic purposes has been confirmed by application of modified enzymes in clinical practice and numerous research data on them.
Intravenous injection of the superoxide dismutase-chondroitin sulfate-catalase (SOD-CHS-CAT) conjugate in preventive and medicative regimes in rats with endotoxin shock induced with a lipopolysaccharide bolus has demonstrated that antioxidant agents not only effectively prevent damage caused by oxidative stress (as believed previously) but also can be used for antioxidative stress therapy.
The results obtained emphasize the importance of investigation into the pathogenesis of vascular damage and the role of oxidative stress in it.
The effects of intravenous medicative injection of SOD-CHS-CAT in a rat model of endotoxin shock have demonstrated a variety in the activity of this conjugate in addition to prevention of NO conversion in peroxynitrite upon interaction with O 2 ∙ - superoxide radical.
Together with the literature data, these findings offer a prospect for the study of NO-independent therapeutic effects of SOD-CHS-CAT, implying the importance of a better insight into the mechanisms of the conjugate activity in modeled cardiovascular damage involving vasoactive agents other than NO.
American Psychological Association (APA)
Maksimenko, Alexander V.. 2016. Widening and Elaboration of Consecutive Research into Therapeutic Antioxidant Enzyme Derivatives. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113766
Modern Language Association (MLA)
Maksimenko, Alexander V.. Widening and Elaboration of Consecutive Research into Therapeutic Antioxidant Enzyme Derivatives. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1113766
American Medical Association (AMA)
Maksimenko, Alexander V.. Widening and Elaboration of Consecutive Research into Therapeutic Antioxidant Enzyme Derivatives. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113766
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113766