Efficiency of Base Excision Repair of Oxidative DNA Damage and Its Impact on the Risk of Colorectal Cancer in the Polish Population
Joint Authors
Majsterek, Ireneusz
Markiewicz, Lukasz
Kabzinski, J.
Mucha, B.
Cuchra, M.
Przybylowska, K.
Dziki, A.
Dziki, L.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
DNA oxidative lesions are widely considered as a potential risk factor for colorectal cancer development.
The aim of this work was to determine the role of the efficiency of base excision repair, both in lymphocytes and in epithelial tissue, in patients with CRC and healthy subjects.
SNPs were identified within genes responsible for steps following glycosylase action in BER, and patients and healthy subjects were genotyped.
A radioisotopic BER assay was used for assessing repair efficiency and TaqMan for genotyping.
Decreased BER activity was observed in lymphocyte extract from CRC patients and in cancer tissue extract, compared to healthy subjects.
In addition, polymorphisms of EXO1, LIG3, and PolB may modulate the risk of colorectal cancer by decreasing (PolB) or increasing (LIG3 and EXO1) the chance of malignant transformation.
American Psychological Association (APA)
Kabzinski, J.& Mucha, B.& Cuchra, M.& Markiewicz, Lukasz& Przybylowska, K.& Dziki, A.…[et al.]. 2015. Efficiency of Base Excision Repair of Oxidative DNA Damage and Its Impact on the Risk of Colorectal Cancer in the Polish Population. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113769
Modern Language Association (MLA)
Kabzinski, J.…[et al.]. Efficiency of Base Excision Repair of Oxidative DNA Damage and Its Impact on the Risk of Colorectal Cancer in the Polish Population. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1113769
American Medical Association (AMA)
Kabzinski, J.& Mucha, B.& Cuchra, M.& Markiewicz, Lukasz& Przybylowska, K.& Dziki, A.…[et al.]. Efficiency of Base Excision Repair of Oxidative DNA Damage and Its Impact on the Risk of Colorectal Cancer in the Polish Population. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113769
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113769
