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Role of Natural Stilbenes in the Prevention of Cancer
Joint Authors
Sirerol, J. Antoni
Rodríguez, María L.
Mena, Salvador
Asensi, Miguel A.
Estrela, José M.
Ortega, Angel L.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-21
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Natural stilbenes are an important group of nonflavonoid phytochemicals of polyphenolic structure characterized by the presence of a 1,2-diphenylethylene nucleus.
Stilbenes have an extraordinary potential for the prevention and treatment of different diseases, including cancer, due to their antioxidant, cell death activation, and anti-inflammatory properties which associate with low toxicity under in vivo conditions.
This review aims to discuss various approaches related to their mechanisms of action, pharmacological activities in animal models and humans, and potential chemoprevention in clinical studies.
The biological activity of natural stilbenes is still incompletely understood.
Furthermore, after administration to animals or humans, these molecules are rapidly metabolized.
Thus pharmacokinetics and/or activities of the natural structures and their metabolites may be very different.
Novel drug formulations have been postulated in order to improve stability and bioavailability, to minimize side effects, and to facilitate interaction with their domains in target proteins.
These pharmacological improvements should lead stilbenes to become effective candidates as anticancer drugs.
American Psychological Association (APA)
Sirerol, J. Antoni& Rodríguez, María L.& Mena, Salvador& Asensi, Miguel A.& Estrela, José M.& Ortega, Angel L.. 2015. Role of Natural Stilbenes in the Prevention of Cancer. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1113773
Modern Language Association (MLA)
Sirerol, J. Antoni…[et al.]. Role of Natural Stilbenes in the Prevention of Cancer. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-15.
https://search.emarefa.net/detail/BIM-1113773
American Medical Association (AMA)
Sirerol, J. Antoni& Rodríguez, María L.& Mena, Salvador& Asensi, Miguel A.& Estrela, José M.& Ortega, Angel L.. Role of Natural Stilbenes in the Prevention of Cancer. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1113773
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113773