Autistic-Like Behaviors, Oxidative Stress Status, and Histopathological Changes in Cerebellum of Valproic Acid Rat Model of Autism Are Improved by the Combined Extract of Purple Rice and Silkworm Pupae
Joint Authors
Wattanathorn, Jintanaporn
Morakotsriwan, Nartnutda
Chaisiwamongkol, Kowit
Kirisattayakul, Woranan
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Due to the crucial role of oxidative stress on the pathophysiology of autism and the concept of synergistic effect, the benefit of the combined extract of purple rice and silkworm pupae (AP1) for autism disorder was the focus.
Therefore, we aimed to determine the effect of AP1 on autistic-like behaviors, oxidative stress status, and histopathological change of cerebellum in valproic acid (VPA) rat model of autism.
VPA was injected on postnatal day (PND) 14 and the animals were orally given AP1 at doses of 50, 100, and 200 mg·kg−1 BW between PND 14 and PND 40.
The autism-like behaviors were analyzed via hot-plate, rotarod, elevated plus-maze, learning, memory, and social behavior tests.
Oxidative stress and the histological change in the cerebellum were assessed at the end of study.
AP1 treated rats improved behaviors in all tests except that in hot-plate test.
The improvement of oxidative stress and Purkinje cell loss was also observed in the cerebellum of VPA-treated rats.
Our data suggest that AP1 partially reduced autism-like behaviors by improving oxidative stress and Purkinje cell loss.
Further research is required to identify the active ingredients in AP1 and gender difference effect.
American Psychological Association (APA)
Morakotsriwan, Nartnutda& Wattanathorn, Jintanaporn& Kirisattayakul, Woranan& Chaisiwamongkol, Kowit. 2016. Autistic-Like Behaviors, Oxidative Stress Status, and Histopathological Changes in Cerebellum of Valproic Acid Rat Model of Autism Are Improved by the Combined Extract of Purple Rice and Silkworm Pupae. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113790
Modern Language Association (MLA)
Morakotsriwan, Nartnutda…[et al.]. Autistic-Like Behaviors, Oxidative Stress Status, and Histopathological Changes in Cerebellum of Valproic Acid Rat Model of Autism Are Improved by the Combined Extract of Purple Rice and Silkworm Pupae. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1113790
American Medical Association (AMA)
Morakotsriwan, Nartnutda& Wattanathorn, Jintanaporn& Kirisattayakul, Woranan& Chaisiwamongkol, Kowit. Autistic-Like Behaviors, Oxidative Stress Status, and Histopathological Changes in Cerebellum of Valproic Acid Rat Model of Autism Are Improved by the Combined Extract of Purple Rice and Silkworm Pupae. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113790
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113790