Dysfunction of Autophagy: A Possible Mechanism Involved in the Pathogenesis of Vitiligo by Breaking the Redox Balance of Melanocytes
Joint Authors
Qiao, Zhuhui
Wang, Xiuxiu
Xiang, Leihong
Zhang, Chengfeng
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Vitiligo is a common chronic acquired pigmentation disorder characterized by loss of functional melanocytes from the epidermis and follicular reservoir.
Among multiple hypotheses which have been proposed in the pathogenesis of vitiligo, autoimmunity and oxidative stress-mediated toxicity in melanocytes remain most widely accepted.
Macroautophagy is a lysosome-dependent degradation pathway which widely exists in eukaryotic cells.
Autophagy participates in the oxidative stress response in many cells, which plays a protective role in preventing damage caused by oxidative stress.
Recent studies have enrolled autophagy as an important regulator in limiting damage caused by UV light and lipid oxidation, keeping oxidative stress in a steady state in epidermal keratinocytes and maintaining normal proliferation and aging of melanocytes.
Impairment of autophagy might disrupt the antioxidant defense system which renders melanocytes to oxidative insults.
These findings provide supportive evidence to explore new ideas of the pathogenesis of vitiligo and other pigmentation disorders.
American Psychological Association (APA)
Qiao, Zhuhui& Wang, Xiuxiu& Xiang, Leihong& Zhang, Chengfeng. 2016. Dysfunction of Autophagy: A Possible Mechanism Involved in the Pathogenesis of Vitiligo by Breaking the Redox Balance of Melanocytes. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1113804
Modern Language Association (MLA)
Qiao, Zhuhui…[et al.]. Dysfunction of Autophagy: A Possible Mechanism Involved in the Pathogenesis of Vitiligo by Breaking the Redox Balance of Melanocytes. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1113804
American Medical Association (AMA)
Qiao, Zhuhui& Wang, Xiuxiu& Xiang, Leihong& Zhang, Chengfeng. Dysfunction of Autophagy: A Possible Mechanism Involved in the Pathogenesis of Vitiligo by Breaking the Redox Balance of Melanocytes. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1113804
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113804