Melatoninergic System in Parkinson’s Disease: From Neuroprotection to the Management of Motor and Nonmotor Symptoms
Joint Authors
Prediger, Rui Daniel
Mack, Josiel Mileno
Schamne, Marissa Giovanna
Sampaio, Tuane Bazanella
Pértile, Renata Aparecida Nedel
Fernandes, Pedro Augusto Carlos Magno
Markus, Regina P.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-31, 31 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-18
Country of Publication
Egypt
No. of Pages
31
Main Subjects
Abstract EN
Melatonin is synthesized by several tissues besides the pineal gland, and beyond its regulatory effects in light-dark cycle, melatonin is a hormone with neuroprotective, anti-inflammatory, and antioxidant properties.
Melatonin acts as a free-radical scavenger, reducing reactive species and improving mitochondrial homeostasis.
Melatonin also regulates the expression of neurotrophins that are involved in the survival of dopaminergic neurons and reduces α-synuclein aggregation, thus protecting the dopaminergic system against damage.
The unbalance of pineal melatonin synthesis can predispose the organism to inflammatory and neurodegenerative diseases such as Parkinson’s disease (PD).
The aim of this review is to summarize the knowledge about the potential role of the melatoninergic system in the pathogenesis and treatment of PD.
The literature reviewed here indicates that PD is associated with impaired brain expression of melatonin and its receptors MT1 and MT2.
Exogenous melatonin treatment presented an outstanding neuroprotective effect in animal models of PD induced by different toxins, such as 6-hydroxydopamine (6-OHDA), 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), rotenone, paraquat, and maneb.
Despite the neuroprotective effects and the improvement of motor impairments, melatonin also presents the potential to improve nonmotor symptoms commonly experienced by PD patients such as sleep and anxiety disorders, depression, and memory dysfunction.
American Psychological Association (APA)
Mack, Josiel Mileno& Schamne, Marissa Giovanna& Sampaio, Tuane Bazanella& Pértile, Renata Aparecida Nedel& Fernandes, Pedro Augusto Carlos Magno& Markus, Regina P.…[et al.]. 2016. Melatoninergic System in Parkinson’s Disease: From Neuroprotection to the Management of Motor and Nonmotor Symptoms. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-31.
https://search.emarefa.net/detail/BIM-1113817
Modern Language Association (MLA)
Mack, Josiel Mileno…[et al.]. Melatoninergic System in Parkinson’s Disease: From Neuroprotection to the Management of Motor and Nonmotor Symptoms. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-31.
https://search.emarefa.net/detail/BIM-1113817
American Medical Association (AMA)
Mack, Josiel Mileno& Schamne, Marissa Giovanna& Sampaio, Tuane Bazanella& Pértile, Renata Aparecida Nedel& Fernandes, Pedro Augusto Carlos Magno& Markus, Regina P.…[et al.]. Melatoninergic System in Parkinson’s Disease: From Neuroprotection to the Management of Motor and Nonmotor Symptoms. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-31.
https://search.emarefa.net/detail/BIM-1113817
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113817