Maladaptive Modulations of NLRP3 Inflammasome and Cardioprotective Pathways Are Involved in Diet-Induced Exacerbation of Myocardial IschemiaReperfusion Injury in Mice
Joint Authors
Collino, Massimo
Pagliaro, Pasquale
Penna, Claudia
Fracasso, Veronica
Tullio, Francesca
Mastrocola, Raffaella
Nigro, Debora
Chiazza, Fausto
Aragno, Manuela
Alloatti, Giuseppe
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-14
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Excessive fatty acids and sugars intake is known to affect the development of cardiovascular diseases, including myocardial infarction.
However, the underlying mechanisms are ill defined.
Here we investigated the balance between prosurvival and detrimental pathways within the heart of C57Bl/6 male mice fed a standard diet (SD) or a high-fat high-fructose diet (HFHF) for 12 weeks and exposed to cardiac ex vivo ischemia/reperfusion (IR) injury.
Dietary manipulation evokes a maladaptive response in heart mice, as demonstrated by the shift of myosin heavy chain isoform content from α to β, the increased expression of the Nlrp3 inflammasome and markers of oxidative metabolism, and the downregulation of the hypoxia inducible factor- (HIF-)2α and members of the Reperfusion Injury Salvage Kinases (RISK) pathway.
When exposed to IR, HFHF mice hearts showed greater infarct size and lactic dehydrogenase release in comparison with SD mice.
These effects were associated with an exacerbated overexpression of Nlrp3 inflammasome, resulting in marked caspase-1 activation and a compromised activation of the cardioprotective RISK/HIF-2α pathways.
The common mechanisms of damage here reported lead to a better understanding of the cross-talk among prosurvival and detrimental pathways leading to the development of cardiovascular disorders associated with metabolic diseases.
American Psychological Association (APA)
Mastrocola, Raffaella& Collino, Massimo& Penna, Claudia& Nigro, Debora& Chiazza, Fausto& Fracasso, Veronica…[et al.]. 2015. Maladaptive Modulations of NLRP3 Inflammasome and Cardioprotective Pathways Are Involved in Diet-Induced Exacerbation of Myocardial IschemiaReperfusion Injury in Mice. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1113819
Modern Language Association (MLA)
Mastrocola, Raffaella…[et al.]. Maladaptive Modulations of NLRP3 Inflammasome and Cardioprotective Pathways Are Involved in Diet-Induced Exacerbation of Myocardial IschemiaReperfusion Injury in Mice. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1113819
American Medical Association (AMA)
Mastrocola, Raffaella& Collino, Massimo& Penna, Claudia& Nigro, Debora& Chiazza, Fausto& Fracasso, Veronica…[et al.]. Maladaptive Modulations of NLRP3 Inflammasome and Cardioprotective Pathways Are Involved in Diet-Induced Exacerbation of Myocardial IschemiaReperfusion Injury in Mice. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1113819
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113819