Inhibition of HSP90 Promotes Neural Stem Cell Survival from Oxidative Stress through Attenuating NF-κBp65 Activation
Joint Authors
Liu, Xinfeng
Liu, Qian
Li, Yun
Jiang, Wenkai
Li, Yunzi
Zhou, Lin
Song, Bing
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Stem cell survival after transplantation determines the efficiency of stem cell treatment, which develops as a novel potential therapy for several central nervous system (CNS) diseases in recent decades.
The engrafted stem cells face the damage of oxidative stress, inflammation, and immune response at the lesion point in host.
Among the damaging pathologies, oxidative stress directs stem cells to apoptosis and even death through several signalling pathways and DNA damage.
However, the in-detail mechanism of stem cell survival from oxidative stress has not been revealed clearly.
Here, in this study, we used hydrogen peroxide (H2O2) to induce the oxidative damage on neural stem cells (NSCs).
The damage was in consequence demonstrated involving the activation of heat shock protein 90 (HSP90) and NF- κ B/p65 signalling pathways.
Further application of the pharmacological inhibitors, respectively, targeting at each signalling indicated an upper-stream role of HSP90 upon NF- κ B/p65 on NSCs survival.
Preinhibition of HSP90 with the specific inhibitor displayed a significant protection on NSCs against oxidative stress.
In conclusion, inhibition of HSP90 would attenuate NF- κ B/p65 activation by oxidative induction and promote NSCs survival from oxidative damage.
The HSP90/NF- κ B mechanism provides a new evidence on rescuing NSCs from oxidative stress and also promotes the stem cell application on CNS pathologies.
American Psychological Association (APA)
Liu, Qian& Li, Yun& Jiang, Wenkai& Li, Yunzi& Zhou, Lin& Song, Bing…[et al.]. 2016. Inhibition of HSP90 Promotes Neural Stem Cell Survival from Oxidative Stress through Attenuating NF-κBp65 Activation. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113820
Modern Language Association (MLA)
Liu, Qian…[et al.]. Inhibition of HSP90 Promotes Neural Stem Cell Survival from Oxidative Stress through Attenuating NF-κBp65 Activation. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1113820
American Medical Association (AMA)
Liu, Qian& Li, Yun& Jiang, Wenkai& Li, Yunzi& Zhou, Lin& Song, Bing…[et al.]. Inhibition of HSP90 Promotes Neural Stem Cell Survival from Oxidative Stress through Attenuating NF-κBp65 Activation. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113820
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113820