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Is Liver Enzyme Release Really Associated with Cell Necrosis Induced by Oxidant Stress?
Joint Authors
Contreras-Zentella, Martha Lucinda
Hernández-Muñoz, Rolando
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-20
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Hepatic diseases are a major concern worldwide.
Increased specific plasma enzyme activities are considered diagnostic features for liver diseases, since enzymes are released into the blood compartment following the deterioration of the organ.
Release of liver mitochondrial enzymes is considered strong evidence for hepatic necrosis, which is associated with an increased production of ROS, often leading to greater hepatic lipid peroxidation.
Lipotoxic mediators and intracellular signals activated Kupffer cells, which provides evidence strongly suggesting the participation of oxidant stress in acute liver damage, inducing the progression of liver injury to chronic liver damage.
Elevated transaminase activities are considered as an index marker of hepatotoxicity, linked to oxidant stress.
However, a drastic increase of serum activities of liver enzyme markers ought not necessarily to reflect liver cell death.
In fact, increased serum levels of cytoplasmic enzymes have readily been observed after partial hepatectomy (PH) in the regenerating liver of rats.
In this regard, we are now showing that in vitro modifications of the oxidant status affect differentially the release of liver enzymes, indicating that this release is a strictly controlled event and not directly related to the onset of oxidant stress of the liver.
American Psychological Association (APA)
Contreras-Zentella, Martha Lucinda& Hernández-Muñoz, Rolando. 2015. Is Liver Enzyme Release Really Associated with Cell Necrosis Induced by Oxidant Stress?. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1113825
Modern Language Association (MLA)
Contreras-Zentella, Martha Lucinda& Hernández-Muñoz, Rolando. Is Liver Enzyme Release Really Associated with Cell Necrosis Induced by Oxidant Stress?. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1113825
American Medical Association (AMA)
Contreras-Zentella, Martha Lucinda& Hernández-Muñoz, Rolando. Is Liver Enzyme Release Really Associated with Cell Necrosis Induced by Oxidant Stress?. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1113825
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113825