Vascular Ageing and Exercise: Focus on Cellular Reparative Processes
Joint Authors
Ross, Mark D.
Malone, Eva
Florida-James, Geraint
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-01
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Ageing is associated with an increased risk of developing noncommunicable diseases (NCDs), such as diabetes and cardiovascular disease (CVD).
The increased risk can be attributable to increased prolonged exposure to oxidative stress.
Often, CVD is preceded by endothelial dysfunction, which carries with it a proatherothrombotic phenotype.
Endothelial senescence and reduced production and release of nitric oxide (NO) are associated with “vascular ageing” and are often accompanied by a reduced ability for the body to repair vascular damage, termed “reendothelialization.” Exercise has been repeatedly shown to confer protection against CVD and diabetes risk and incidence.
Regular exercise promotes endothelial function and can prevent endothelial senescence, often through a reduction in oxidative stress.
Recently, endothelial precursors, endothelial progenitor cells (EPC), have been shown to repair damaged endothelium, and reduced circulating number and/or function of these cells is associated with ageing.
Exercise can modulate both number and function of these cells to promote endothelial homeostasis.
In this review we look at the effects of advancing age on the endothelium and these endothelial precursors and how exercise appears to offset this “vascular ageing” process.
American Psychological Association (APA)
Ross, Mark D.& Malone, Eva& Florida-James, Geraint. 2015. Vascular Ageing and Exercise: Focus on Cellular Reparative Processes. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1113839
Modern Language Association (MLA)
Ross, Mark D.…[et al.]. Vascular Ageing and Exercise: Focus on Cellular Reparative Processes. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-15.
https://search.emarefa.net/detail/BIM-1113839
American Medical Association (AMA)
Ross, Mark D.& Malone, Eva& Florida-James, Geraint. Vascular Ageing and Exercise: Focus on Cellular Reparative Processes. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1113839
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113839