DNA Damage in Chronic Kidney Disease: Evaluation of Clinical Biomarkers
Joint Authors
Heidland, A.
Schupp, Nicole
Stopper, Helga
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Patients with chronic kidney disease (CKD) exhibit an increased cancer risk compared to a healthy control population.
To be able to estimate the cancer risk of the patients and to assess the impact of interventional therapies thereon, it is of particular interest to measure the patients’ burden of genomic damage.
Chromosomal abnormalities, reduced DNA repair, and DNA lesions were found indeed in cells of patients with CKD.
Biomarkers for DNA damage measurable in easily accessible cells like peripheral blood lymphocytes are chromosomal aberrations, structural DNA lesions, and oxidatively modified DNA bases.
In this review the most common methods quantifying the three parameters mentioned above, the cytokinesis-block micronucleus assay, the comet assay, and the quantification of 8-oxo-7,8-dihydro-2′-deoxyguanosine, are evaluated concerning the feasibility of the analysis and regarding the marker’s potential to predict clinical outcomes.
American Psychological Association (APA)
Schupp, Nicole& Stopper, Helga& Heidland, A.. 2016. DNA Damage in Chronic Kidney Disease: Evaluation of Clinical Biomarkers. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113841
Modern Language Association (MLA)
Schupp, Nicole…[et al.]. DNA Damage in Chronic Kidney Disease: Evaluation of Clinical Biomarkers. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1113841
American Medical Association (AMA)
Schupp, Nicole& Stopper, Helga& Heidland, A.. DNA Damage in Chronic Kidney Disease: Evaluation of Clinical Biomarkers. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113841
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113841