Extracellular Superoxide Dismutase: Growth Promoter or Tumor Suppressor?
Author
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Extracellular superoxide dismutase (SOD3) gene transfer to tissue damage results in increased healing, increased cell proliferation, decreased apoptosis, and decreased inflammatory cell infiltration.
At molecular level, in vivo SOD3 overexpression reduces superoxide anion ( O 2 - ) concentration and increases mitogen kinase activation suggesting that SOD3 could have life-supporting characteristics.
The hypothesis is further strengthened by the observations showing significantly increased mortality in conditional knockout mice.
However, in cancer SOD3 has been shown to either increase or decrease cell proliferation and survival depending on the model system used, indicating that SOD3-derived growth mechanisms are not completely understood.
In this paper, the author reviews the main discoveries in SOD3-dependent growth regulation and signal transduction.
American Psychological Association (APA)
Laukkanen, Mikko O.. 2016. Extracellular Superoxide Dismutase: Growth Promoter or Tumor Suppressor?. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113843
Modern Language Association (MLA)
Laukkanen, Mikko O.. Extracellular Superoxide Dismutase: Growth Promoter or Tumor Suppressor?. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1113843
American Medical Association (AMA)
Laukkanen, Mikko O.. Extracellular Superoxide Dismutase: Growth Promoter or Tumor Suppressor?. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113843
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113843