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Oxidative Stress in Children with Chronic Spontaneous Urticaria
Joint Authors
Dilek, Fatih
Ozceker, Deniz
Ozkaya, Emin
Guler, Nermin
Tamay, Zeynep
Kesgin, Siddika
Yazici, Mebrure
Kocyigit, Abdurrahim
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The pathogenesis of chronic spontaneous urticaria (CSU) has not been fully understood; nevertheless, significant progress has been achieved in recent years.
The aim of this study was to investigate the possible role of reactive oxygen species (ROS) in the pathogenesis of CSU.
Sixty-two children with CSU and 41 healthy control subjects were enrolled in the study.
An extensive evaluation of demographic and clinical features was done, and serum oxidative stress was evaluated by plasma total oxidant status (TOS) and total antioxidant status (TAS) measurements.
The median value of plasma TOS was found to be 10.49 μmol H2O2 equiv./L (interquartile range, 7.29–17.65) in CSU patients and 7.68 μmol H2O2 equiv./L (5.95–10.39) in the control group.
The difference between the groups was statistically significant ( p = 0.003 ).
Likewise, the median plasma TAS level in the CSU group was decreased significantly compared to that of the control group (2.64 [2.30–2.74] versus 2.76 [2.65–2.86] mmol Trolox equiv./L, resp., p = 0,001).
Our results indicated that plasma oxidative stress is increased in children with CSU when compared to healthy subjects, and plasma oxidative stress markers are positively correlated with disease activity.
American Psychological Association (APA)
Dilek, Fatih& Ozceker, Deniz& Ozkaya, Emin& Guler, Nermin& Tamay, Zeynep& Kesgin, Siddika…[et al.]. 2016. Oxidative Stress in Children with Chronic Spontaneous Urticaria. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1113854
Modern Language Association (MLA)
Dilek, Fatih…[et al.]. Oxidative Stress in Children with Chronic Spontaneous Urticaria. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1113854
American Medical Association (AMA)
Dilek, Fatih& Ozceker, Deniz& Ozkaya, Emin& Guler, Nermin& Tamay, Zeynep& Kesgin, Siddika…[et al.]. Oxidative Stress in Children with Chronic Spontaneous Urticaria. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1113854
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113854