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Alteration of Neutrophil Reactive Oxygen Species Production by Extracts of Devil’s Claw (Harpagophytum)
Joint Authors
Widén, C.
Rumpunen, K.
Muzila, Mbaki
Wright, Helen
Roberts, Helen
Grant, Melissa
Nybom, Hilde
Sehic, Jasna
Ekholm, A.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Harpagophytum, Devil’s Claw, is a genus of tuberiferous xerophytic plants native to southern Africa.
Some of the taxa are appreciated for their medicinal effects and have been traditionally used to relieve symptoms of inflammation.
The objectives of this pilot study were to investigate the antioxidant capacity and the content of total phenols, verbascoside, isoverbascoside, and selected iridoids, as well as to investigate the capacity of various Harpagophytum taxa in suppressing respiratory burst in terms of reactive oxygen species produced by human neutrophils challenged with phorbol myristate acetate (PMA), opsonised Staphylococcus aureus, and Fusobacterium nucleatum.
Harpagophytum plants were classified into different taxa according to morphology, and DNA analysis was used to confirm the classification.
A putative new variety of H.
procumbens showed the highest degree of antioxidative capacity.
Using PMA, three Harpagophytum taxa showed anti-inflammatory effects with regard to the PBS control.
A putative hybrid between H.
procumbens and H.
zeyheri in contrast showed proinflammatory effect on the response of neutrophils to F.
nucleatum in comparison with treatment with vehicle control.
Harpagophytum taxa were biochemically very variable and the response in suppressing respiratory burst differed.
Further studies with larger number of subjects are needed to corroborate anti-inflammatory effects of different taxa of Harpagophytum.
American Psychological Association (APA)
Muzila, Mbaki& Rumpunen, K.& Wright, Helen& Roberts, Helen& Grant, Melissa& Nybom, Hilde…[et al.]. 2016. Alteration of Neutrophil Reactive Oxygen Species Production by Extracts of Devil’s Claw (Harpagophytum). Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113856
Modern Language Association (MLA)
Muzila, Mbaki…[et al.]. Alteration of Neutrophil Reactive Oxygen Species Production by Extracts of Devil’s Claw (Harpagophytum). Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1113856
American Medical Association (AMA)
Muzila, Mbaki& Rumpunen, K.& Wright, Helen& Roberts, Helen& Grant, Melissa& Nybom, Hilde…[et al.]. Alteration of Neutrophil Reactive Oxygen Species Production by Extracts of Devil’s Claw (Harpagophytum). Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113856
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113856