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Modulation of Hypercholesterolemia-Induced OxidativeNitrative Stress in the Heart
Joint Authors
Csont, Tamás
Csonka, Csaba
Sárközy, Márta
Pipicz, Márton
Dux, László
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-23, 23 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-14
Country of Publication
Egypt
No. of Pages
23
Main Subjects
Abstract EN
Hypercholesterolemia is a frequent metabolic disorder associated with increased risk for cardiovascular morbidity and mortality.
In addition to its well-known proatherogenic effect, hypercholesterolemia may exert direct effects on the myocardium resulting in contractile dysfunction, aggravated ischemia/reperfusion injury, and diminished stress adaptation.
Both preclinical and clinical studies suggested that elevated oxidative and/or nitrative stress plays a key role in cardiac complications induced by hypercholesterolemia.
Therefore, modulation of hypercholesterolemia-induced myocardial oxidative/nitrative stress is a feasible approach to prevent or treat deleterious cardiac consequences.
In this review, we discuss the effects of various pharmaceuticals, nutraceuticals, some novel potential pharmacological approaches, and physical exercise on hypercholesterolemia-induced oxidative/nitrative stress and subsequent cardiac dysfunction as well as impaired ischemic stress adaptation of the heart in hypercholesterolemia.
American Psychological Association (APA)
Csonka, Csaba& Sárközy, Márta& Pipicz, Márton& Dux, László& Csont, Tamás. 2015. Modulation of Hypercholesterolemia-Induced OxidativeNitrative Stress in the Heart. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-23.
https://search.emarefa.net/detail/BIM-1113861
Modern Language Association (MLA)
Csonka, Csaba…[et al.]. Modulation of Hypercholesterolemia-Induced OxidativeNitrative Stress in the Heart. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-23.
https://search.emarefa.net/detail/BIM-1113861
American Medical Association (AMA)
Csonka, Csaba& Sárközy, Márta& Pipicz, Márton& Dux, László& Csont, Tamás. Modulation of Hypercholesterolemia-Induced OxidativeNitrative Stress in the Heart. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-23.
https://search.emarefa.net/detail/BIM-1113861
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113861