![](/images/graphics-bg.png)
The Dual Function of Reactive OxygenNitrogen Species in Bioenergetics and Cell Death: The Role of ATP Synthase
Joint Authors
Kaludercic, Nina
Giorgio, Valentina
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-10
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) targeting mitochondria are major causative factors in disease pathogenesis.
The mitochondrial permeability transition pore (PTP) is a mega-channel modulated by calcium and ROS/RNS modifications and it has been described to play a crucial role in many pathophysiological events since prolonged channel opening causes cell death.
The recent identification that dimers of ATP synthase form the PTP and the fact that posttranslational modifications caused by ROS/RNS also affect cellular bioenergetics through the modulation of ATP synthase catalysis reveal a dual function of these modifications in the cells.
Here, we describe mitochondria as a major site of production and as a target of ROS/RNS and discuss the pathophysiological conditions in which oxidative and nitrosative modifications modulate the catalytic and pore-forming activities of ATP synthase.
American Psychological Association (APA)
Kaludercic, Nina& Giorgio, Valentina. 2016. The Dual Function of Reactive OxygenNitrogen Species in Bioenergetics and Cell Death: The Role of ATP Synthase. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1113863
Modern Language Association (MLA)
Kaludercic, Nina& Giorgio, Valentina. The Dual Function of Reactive OxygenNitrogen Species in Bioenergetics and Cell Death: The Role of ATP Synthase. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-17.
https://search.emarefa.net/detail/BIM-1113863
American Medical Association (AMA)
Kaludercic, Nina& Giorgio, Valentina. The Dual Function of Reactive OxygenNitrogen Species in Bioenergetics and Cell Death: The Role of ATP Synthase. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1113863
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113863