The Interplay of Reactive Oxygen Species, Hypoxia, Inflammation, and Sirtuins in Cancer Initiation and Progression
Joint Authors
Russo, M. A.
Tafani, M.
Sansone, Luigi
Limana, Federica
Arcangeli, Tania
De Santis, Elena
Polese, Milena
Fini, Massimo
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-20
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
The presence of ROS is a constant feature in living cells metabolizing O2.
ROS concentration and compartmentation determine their physiological or pathological effects.
ROS overproduction is a feature of cancer cells and plays several roles during the natural history of malignant tumor.
ROS continuously contribute to each step of cancerogenesis, from the initiation to the malignant progression, acting directly or indirectly.
In this review, we will (a) underline the role of ROS in the pathway leading a normal cell to tumor transformation and progression, (b) define the multiple roles of ROS during the natural history of a tumor, (c) conciliate many conflicting data about harmful or beneficial effects of ROS, (d) rethink the importance of oncogene and tumor suppressor gene mutations in relation to the malignant progression, and (e) collocate all the cancer hallmarks in a mechanistic sequence which could represent a “physiological” response to the initial growth of a transformed stem/pluripotent cell, defining also the role of ROS in each hallmark.
We will provide a simplified sketch about the relationships between ROS and cancer.
The attention will be focused on the contribution of ROS to the signaling of HIF, NFκB, and Sirtuins as a leitmotif of cancer initiation and progression.
American Psychological Association (APA)
Tafani, M.& Sansone, Luigi& Limana, Federica& Arcangeli, Tania& De Santis, Elena& Polese, Milena…[et al.]. 2015. The Interplay of Reactive Oxygen Species, Hypoxia, Inflammation, and Sirtuins in Cancer Initiation and Progression. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-18.
https://search.emarefa.net/detail/BIM-1113867
Modern Language Association (MLA)
Tafani, M.…[et al.]. The Interplay of Reactive Oxygen Species, Hypoxia, Inflammation, and Sirtuins in Cancer Initiation and Progression. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-18.
https://search.emarefa.net/detail/BIM-1113867
American Medical Association (AMA)
Tafani, M.& Sansone, Luigi& Limana, Federica& Arcangeli, Tania& De Santis, Elena& Polese, Milena…[et al.]. The Interplay of Reactive Oxygen Species, Hypoxia, Inflammation, and Sirtuins in Cancer Initiation and Progression. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-18.
https://search.emarefa.net/detail/BIM-1113867
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113867