Ion Channels and Oxidative Stress as a Potential Link for the Diagnosis or Treatment of Liver Diseases
Joint Authors
Camacho, Javier
Ramírez, Ana
Vázquez-Sánchez, Alma Yolanda
Carrión-Robalino, Natalia
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-05
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Oxidative stress results from a disturbed balance between oxidation and antioxidant systems.
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) may be either harmful or beneficial to the cells.
Ion channels are transmembrane proteins that participate in a large variety of cellular functions and have been implicated in the development of a variety of diseases.
A significant amount of the available drugs in the market targets ion channels.
These proteins have sulfhydryl groups of cysteine and methionine residues in their structure that can be targeted by ROS and RNS altering channel function including gating and conducting properties, as well as the corresponding signaling pathways associated.
The regulation of ion channels by ROS has been suggested to be associated with some pathological conditions including liver diseases.
This review focuses on understanding the role and the potential association of ion channels and oxidative stress in liver diseases including fibrosis, alcoholic liver disease, and cancer.
The potential association between ion channels and oxidative stress conditions could be used to develop new treatments for major liver diseases.
American Psychological Association (APA)
Ramírez, Ana& Vázquez-Sánchez, Alma Yolanda& Carrión-Robalino, Natalia& Camacho, Javier. 2016. Ion Channels and Oxidative Stress as a Potential Link for the Diagnosis or Treatment of Liver Diseases. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1113872
Modern Language Association (MLA)
Ramírez, Ana…[et al.]. Ion Channels and Oxidative Stress as a Potential Link for the Diagnosis or Treatment of Liver Diseases. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-17.
https://search.emarefa.net/detail/BIM-1113872
American Medical Association (AMA)
Ramírez, Ana& Vázquez-Sánchez, Alma Yolanda& Carrión-Robalino, Natalia& Camacho, Javier. Ion Channels and Oxidative Stress as a Potential Link for the Diagnosis or Treatment of Liver Diseases. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1113872
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113872