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Oxidant Status following Cardiac Surgery with Phosphorylcholine-Coated Extracorporeal Circulation Systems
Joint Authors
Hatemi, Ali Can
Çeviker, Kadir
Tongut, Aybala
Özgöl, İlhan
Mert, Murat
Kaya, Ayşem
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-23
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Introduction.
Extracorporeal circulation (ECC) related systemic oxidative stress is a well-known entity but the underlying mechanisms are not clearly described.
Our aim was to investigate the relation between the oxidative stress indices, inflammatory markers, and phosphorylcholine-coated (PCC) ECC systems.
Patients and Methods.
Thirty-two consecutive coronary artery bypass grafting (CABG) cases were randomly assigned to Group I (PCC, n=18) and Group II (noncoated, n=14) ECC circuits.
Total Antioxidant Status (TAS), Total Oxidant Status (TOS), Tumor Necrosis Factor-α (TNF-α), Interleukin-1β (IL-β), Interleukin-6 (IL-6), Interleukin-8 (IL-8), Interleukin-10 (IL-10), and Procalcitonin (PCT) levels were measured at 5 different time points.
The association between the oxidative indices levels and PCC system used was analyzed.
Results.
In Group I TOS and TAS statuses were increased at T1, T2, T3, and T4, while IL-10 and TNF-α levels accompanied those raises only at T2 (Group I-Group II, 4.73±2.04 versus 2.79±0.63, p=0.002, and 30.56±8.11 versus 23.97±7.8, p=0.031, resp.).
In contrast, mean TAS and TOS levels were similar to baseline at all time points in Group II but IL-6 and IL-8 levels were increased at T2 (Group I-Group II, 16.84±5.63 versus 44.81±17.0, p=0.001, and 38.88±9.8 versus 46.14±9.25, p=0.038, resp.).
Conclusion.
Even coated ECC systems are still incapable of attenuating the inflammatory response to cardiopulmonary bypass (CPB).
American Psychological Association (APA)
Hatemi, Ali Can& Çeviker, Kadir& Tongut, Aybala& Özgöl, İlhan& Mert, Murat& Kaya, Ayşem. 2016. Oxidant Status following Cardiac Surgery with Phosphorylcholine-Coated Extracorporeal Circulation Systems. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113873
Modern Language Association (MLA)
Hatemi, Ali Can…[et al.]. Oxidant Status following Cardiac Surgery with Phosphorylcholine-Coated Extracorporeal Circulation Systems. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1113873
American Medical Association (AMA)
Hatemi, Ali Can& Çeviker, Kadir& Tongut, Aybala& Özgöl, İlhan& Mert, Murat& Kaya, Ayşem. Oxidant Status following Cardiac Surgery with Phosphorylcholine-Coated Extracorporeal Circulation Systems. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113873
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113873