Modulatory Effect of 2-(4-Hydroxyphenyl)amino-1,4-naphthoquinone on Endothelial Vasodilation in Rat Aorta
Joint Authors
Valderrama, Jaime
Rios, David
Buc Calderon, Pedro
Palacios, Javier
Cifuentes, Fredi
Benites, Julio
González, Constanza
Chiong, Mario
Cartes-Saavedra, Benjamín
Lafourcade, Carlos
Wyneken, Ursula
González, Pamela
Owen, Gareth I.
Pardo, Fabián
Sobrevia, Luis
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-08
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The vascular endothelium plays an essential role in the control of the blood flow.
Pharmacological agents like quinone (menadione) at various doses modulate this process in a variety of ways.
In this study, Q7, a 2-phenylamino-1,4-naphthoquinone derivative, significantly increased oxidative stress and induced vascular dysfunction at concentrations that were not cytotoxic to endothelial or vascular smooth muscle cells.
Q7 reduced nitric oxide (NO) levels and endothelial vasodilation to acetylcholine in rat aorta.
It also blunted the calcium release from intracellular stores by increasing the phenylephrine-induced vasoconstriction when CaCl2 was added to a calcium-free medium but did not affect the influx of calcium from extracellular space.
Q7 increased the vasoconstriction to BaCl2 (10−3 M), an inward rectifying K+ channels blocker, and blocked the vasodilation to KCl (10−2 M) in aortic rings precontracted with BaCl2.
This was recovered with sodium nitroprusside (10−8 M), a NO donor.
In conclusion, Q7 induced vasoconstriction was through a modulation of cellular mechanisms involving calcium fluxes through K+ channels, and oxidative stress induced endothelium damage.
These findings contribute to the characterization of new quinone derivatives with low cytotoxicity able to pharmacologically modulate vasodilation.
American Psychological Association (APA)
Palacios, Javier& Cifuentes, Fredi& Valderrama, Jaime& Benites, Julio& Rios, David& González, Constanza…[et al.]. 2016. Modulatory Effect of 2-(4-Hydroxyphenyl)amino-1,4-naphthoquinone on Endothelial Vasodilation in Rat Aorta. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1113876
Modern Language Association (MLA)
Palacios, Javier…[et al.]. Modulatory Effect of 2-(4-Hydroxyphenyl)amino-1,4-naphthoquinone on Endothelial Vasodilation in Rat Aorta. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1113876
American Medical Association (AMA)
Palacios, Javier& Cifuentes, Fredi& Valderrama, Jaime& Benites, Julio& Rios, David& González, Constanza…[et al.]. Modulatory Effect of 2-(4-Hydroxyphenyl)amino-1,4-naphthoquinone on Endothelial Vasodilation in Rat Aorta. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1113876
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113876