Angiotensin II-Induced Hypertension Is Attenuated by Overexpressing CopperZinc Superoxide Dismutase in the Brain Organum Vasculosum of the Lamina Terminalis
Joint Authors
Zimmerman, Matthew C.
Collister, John P.
Taylor-Smith, Heather
Drebes, Donna
Nahey, David
Tian, Jun
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-06
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Angiotensin II (AngII) can access the brain via circumventricular organs (CVOs), including the subfornical organ (SFO) and organum vasculosum of the lamina terminalis (OVLT), to modulate blood pressure.
Previous studies have demonstrated a role for both the SFO and OVLT in the hypertensive response to chronic AngII, yet it is unclear which intracellular signaling pathways are involved in this response.
Overexpression of copper/zinc superoxide dismutase (CuZnSOD) in the SFO has been shown to attenuate the chronic hypertensive effects of AngII.
Presently, we tested the hypothesis that elevated levels of superoxide ( O 2 ∙ - ) in the OVLT contribute to the hypertensive effects of AngII.
To facilitate overexpression of superoxide dismutase, adenoviral vectors encoding human CuZnSOD or control adenovirus (AdEmpty) were injected directly into the OVLT of rats.
Following 3 days of control saline infusion, rats were intravenously infused with AngII (10 ng/kg/min) for ten days.
Blood pressure increased 33 ± 8 mmHg in AdEmpty rats ( n = 6 ), while rats overexpressing CuZnSOD ( n = 8 ) in the OVLT demonstrated a blood pressure increase of only 18 ± 5 mmHg after 10 days of AngII infusion.
These results support the hypothesis that overproduction of O 2 ∙ - in the OVLT plays an important role in the development of chronic AngII-dependent hypertension.
American Psychological Association (APA)
Collister, John P.& Taylor-Smith, Heather& Drebes, Donna& Nahey, David& Tian, Jun& Zimmerman, Matthew C.. 2016. Angiotensin II-Induced Hypertension Is Attenuated by Overexpressing CopperZinc Superoxide Dismutase in the Brain Organum Vasculosum of the Lamina Terminalis. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113880
Modern Language Association (MLA)
Collister, John P.…[et al.]. Angiotensin II-Induced Hypertension Is Attenuated by Overexpressing CopperZinc Superoxide Dismutase in the Brain Organum Vasculosum of the Lamina Terminalis. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1113880
American Medical Association (AMA)
Collister, John P.& Taylor-Smith, Heather& Drebes, Donna& Nahey, David& Tian, Jun& Zimmerman, Matthew C.. Angiotensin II-Induced Hypertension Is Attenuated by Overexpressing CopperZinc Superoxide Dismutase in the Brain Organum Vasculosum of the Lamina Terminalis. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113880
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113880