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Central Infusion of Angiotensin II Type 2 Receptor Agonist Compound 21 Attenuates DOCANaCl-Induced Hypertension in Female Rats
Joint Authors
Zhang, Yu-Ping
Peng, Wei
Dai, Shu-Yan
Shen, Ying
He, Jing-Jing
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The present study investigated whether central activation of angiotensin II type 2 receptor (AT2-R) attenuates deoxycorticosterone acetate (DOCA)/NaCl-induced hypertension in intact and ovariectomized (OVX) female rats and whether female sex hormone status has influence on the effects of AT2-R activation.
DOCA/NaCl elicited a greater increase in blood pressure in OVX females than that in intact females.
Central infusion of compound 21, a specific AT2-R agonist, abolished DOCA/NaCl pressor effect in intact females, whereas same treatment in OVX females produced an inhibitory effect.
Real-time RT-PCR analysis revealed that DOCA/NaCl enhanced the mRNA expression of hypertensive components including AT1-R, ACE-1, and TNF-α in the paraventricular nucleus of hypothalamus in both intact and OVX females.
However, the mRNA expressions of antihypertensive components such as AT2-R, ACE-2, and IL-10 were increased only in intact females.
Central AT2-R agonist reversed the changes in the hypertensive components in all females, while this agonist further upregulated the expression of ACE2 and IL-10 in intact females, but only IL-10 in OVX females.
These results indicate that brain AT2-R activation plays an inhibitory role in the development of DOCA/NaCl-induced hypertension in females.
This beneficial effect of AT2-R activation involves regulation of renin-angiotensin system and proinflammatory cytokines.
American Psychological Association (APA)
Dai, Shu-Yan& Zhang, Yu-Ping& Peng, Wei& Shen, Ying& He, Jing-Jing. 2015. Central Infusion of Angiotensin II Type 2 Receptor Agonist Compound 21 Attenuates DOCANaCl-Induced Hypertension in Female Rats. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113888
Modern Language Association (MLA)
Dai, Shu-Yan…[et al.]. Central Infusion of Angiotensin II Type 2 Receptor Agonist Compound 21 Attenuates DOCANaCl-Induced Hypertension in Female Rats. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1113888
American Medical Association (AMA)
Dai, Shu-Yan& Zhang, Yu-Ping& Peng, Wei& Shen, Ying& He, Jing-Jing. Central Infusion of Angiotensin II Type 2 Receptor Agonist Compound 21 Attenuates DOCANaCl-Induced Hypertension in Female Rats. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113888
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113888