In Vitro Anti-AChE, Anti-BuChE, and Antioxidant Activity of 12 Extracts of Eleutherococcus Species
Joint Authors
Załuski, Daniel
Kuźniewski, Rafał
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Neurodegenerative diseases are one of the most occurring diseases in developed and developing countries.
The aim of this work focused on the screening of the natural inhibitors of AChE and BuChE and antioxidants in Eleutherococcus species.
We found that the ethanol extracts of E.
setchuenensis and E.
sessiliflorus showed the strongest inhibition towards AChE (IC50: 0.3 and 0.3 mg/mL, resp.).
Among chloroform extracts, the most active appeared to be E.
gracilistylus (IC50: 0.37 mg/mL).
In turn, the ethanol extract of E.
henryi inhibited the strongest BuChE with IC50 value of 0.13 mg/mL.
Among chloroform extracts, E.
gracilistylus, E.
setchuenensis, and E.
sessiliflorus appeared to be the strongest with IC50 values of 0.12, 0.18, and 0.19 mg/mL.
HPTLC screening confirmed the presence of inhibitors in extracts.
All extracts exhibited anti-DPPH⁎ activity and single antioxidants have been identified.
To the best of our knowledge, no information was available on this activity of compounds in Eleutherococcus.
These studies provide a biochemical basis for the regulation of AChE and BuChE and encourage us to continue isolation of active compounds.
American Psychological Association (APA)
Załuski, Daniel& Kuźniewski, Rafał. 2016. In Vitro Anti-AChE, Anti-BuChE, and Antioxidant Activity of 12 Extracts of Eleutherococcus Species. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1113901
Modern Language Association (MLA)
Załuski, Daniel& Kuźniewski, Rafał. In Vitro Anti-AChE, Anti-BuChE, and Antioxidant Activity of 12 Extracts of Eleutherococcus Species. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1113901
American Medical Association (AMA)
Załuski, Daniel& Kuźniewski, Rafał. In Vitro Anti-AChE, Anti-BuChE, and Antioxidant Activity of 12 Extracts of Eleutherococcus Species. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1113901
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113901