Tempol, a Membrane-Permeable Radical Scavenger, Exhibits Anti-Inflammatory and Cardioprotective Effects in the Cerulein-Induced Pancreatitis Rat Model
Joint Authors
Marciniak, Andrzej
Walczyna, Beata
Rajtar, Grażyna
Marciniak, Sebastian
Wojtak, Andrzej
Lasiecka, Katarzyna
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
To date, it remains unclear whether mild form of acute pancreatitis (AP) may cause myocardial damage which may be asymptomatic for a long time.
Pathogenesis of AP-related cardiac injury may be attributed in part to ROS/RNS overproduction.
The aim of the present study was to evaluate the oxidative stress changes in both the pancreas and the heart and to estimate the protective effects of 1-oxyl-2,2,6,6-tetramethyl-4-hydroxypiperidine (tempol) at the early phase of AP.
Cerulein-induced AP led to the development of acute edematous pancreatitis with a significant decrease in the level of sulfhydryl (–SH) groups (oxidation marker) both in heart and in pancreatic tissues as well as a substantial increase in plasma creatine kinase isoenzyme (CK-MB) activity (marker of the heart muscle lesion) which confirmed the role of oxidative stress in the pathogenesis of cardiac damage.
The tempol treatment significantly reduced the intensity of inflammation and oxidative damage and decreased the morphological evidence of pancreas injury at early AP stages.
Moreover, it markedly attenuated AP-induced cardiac damage revealed by normalization of the –SH group levels and CK-MB activity.
On the basis of these studies, it is possible to conclude that tempol has a profound protective effect against cardiac and pancreatic damage induced by AP.
American Psychological Association (APA)
Marciniak, Andrzej& Walczyna, Beata& Rajtar, Grażyna& Marciniak, Sebastian& Wojtak, Andrzej& Lasiecka, Katarzyna. 2015. Tempol, a Membrane-Permeable Radical Scavenger, Exhibits Anti-Inflammatory and Cardioprotective Effects in the Cerulein-Induced Pancreatitis Rat Model. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1113903
Modern Language Association (MLA)
Marciniak, Andrzej…[et al.]. Tempol, a Membrane-Permeable Radical Scavenger, Exhibits Anti-Inflammatory and Cardioprotective Effects in the Cerulein-Induced Pancreatitis Rat Model. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1113903
American Medical Association (AMA)
Marciniak, Andrzej& Walczyna, Beata& Rajtar, Grażyna& Marciniak, Sebastian& Wojtak, Andrzej& Lasiecka, Katarzyna. Tempol, a Membrane-Permeable Radical Scavenger, Exhibits Anti-Inflammatory and Cardioprotective Effects in the Cerulein-Induced Pancreatitis Rat Model. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1113903
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113903