Iron-Mediated Lysosomal Membrane Permeabilization in Ethanol-Induced Hepatic Oxidative Damage and Apoptosis: Protective Effects of Quercetin
Joint Authors
Liu, Liegang
Yao, Ping
Li, Yanyan
Chen, Man
Xu, Yanyan
Yu, Xiao
Xiong, Ting
Du, Min
Sun, Jian
Tang, Yuhan
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-28
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Iron, in its free ferrous states, can catalyze Fenton reaction to produce O H ∙ , which is recognized as a crucial role in the pathogenesis of alcoholic liver diseases (ALD).
As a result of continuous decomposition of iron-containing compounds, lysosomes contain a pool of redox-active iron.
To investigate the important role of intralysosomal iron in alcoholic liver injury and the potential protection of quercetin, male C57BL/6J mice fed by Lieber De Carli diets containing ethanol (30% of total calories) were cotreated by quercetin or deferoxamine (DFO) for 15 weeks and ethanol-incubated mice primary hepatocytes were pretreated with FeCl3, DFO, and bafilomycin A1 at their optimal concentrations and exposure times.
Chronic ethanol consumption caused an evident increase in lysosomal redox-active iron accompanying sustained oxidative damage.
Iron-mediated ROS could trigger lysosomal membrane permeabilization (LMP) and subsequent mitochondria apoptosis.
The hepatotoxicity was attenuated by reducing lysosomal iron while being exacerbated by escalating lysosomal iron.
Quercetin substantially alleviated the alcoholic liver oxidative damage and apoptosis by decreasing lysosome iron and ameliorating iron-mediated LMP, which provided a new prospective of the use of quercetin against ALD.
American Psychological Association (APA)
Li, Yanyan& Chen, Man& Xu, Yanyan& Yu, Xiao& Xiong, Ting& Du, Min…[et al.]. 2015. Iron-Mediated Lysosomal Membrane Permeabilization in Ethanol-Induced Hepatic Oxidative Damage and Apoptosis: Protective Effects of Quercetin. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1113904
Modern Language Association (MLA)
Li, Yanyan…[et al.]. Iron-Mediated Lysosomal Membrane Permeabilization in Ethanol-Induced Hepatic Oxidative Damage and Apoptosis: Protective Effects of Quercetin. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-15.
https://search.emarefa.net/detail/BIM-1113904
American Medical Association (AMA)
Li, Yanyan& Chen, Man& Xu, Yanyan& Yu, Xiao& Xiong, Ting& Du, Min…[et al.]. Iron-Mediated Lysosomal Membrane Permeabilization in Ethanol-Induced Hepatic Oxidative Damage and Apoptosis: Protective Effects of Quercetin. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1113904
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113904