Redox Control of Multidrug Resistance and Its Possible Modulation by Antioxidants
Joint Authors
Korkina, Liudmila
Cort, Aysegul
Ozben, Tomris
De Luca, Chiara
Saso, Luciano
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-05
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Clinical efficacy of anticancer chemotherapies is dramatically hampered by multidrug resistance (MDR) dependent on inherited traits, acquired defence against toxins, and adaptive mechanisms mounting in tumours.
There is overwhelming evidence that molecular events leading to MDR are regulated by redox mechanisms.
For example, chemotherapeutics which overrun the first obstacle of redox-regulated cellular uptake channels (MDR1, MDR2, and MDR3) induce a concerted action of phase I/II metabolic enzymes with a temporal redox-regulated axis.
This results in rapid metabolic transformation and elimination of a toxin.
This metabolic axis is tightly interconnected with the inducible Nrf2-linked pathway, a key switch-on mechanism for upregulation of endogenous antioxidant enzymes and detoxifying systems.
As a result, chemotherapeutics and cytotoxic by-products of their metabolism (ROS, hydroperoxides, and aldehydes) are inactivated and MDR occurs.
On the other hand, tumour cells are capable of mounting an adaptive antioxidant response against ROS produced by chemotherapeutics and host immune cells.
The multiple redox-dependent mechanisms involved in MDR prompted suggesting redox-active drugs (antioxidants and prooxidants) or inhibitors of inducible antioxidant defence as a novel approach to diminish MDR.
Pitfalls and progress in this direction are discussed.
American Psychological Association (APA)
Cort, Aysegul& Ozben, Tomris& Saso, Luciano& De Luca, Chiara& Korkina, Liudmila. 2016. Redox Control of Multidrug Resistance and Its Possible Modulation by Antioxidants. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1113913
Modern Language Association (MLA)
Cort, Aysegul…[et al.]. Redox Control of Multidrug Resistance and Its Possible Modulation by Antioxidants. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-17.
https://search.emarefa.net/detail/BIM-1113913
American Medical Association (AMA)
Cort, Aysegul& Ozben, Tomris& Saso, Luciano& De Luca, Chiara& Korkina, Liudmila. Redox Control of Multidrug Resistance and Its Possible Modulation by Antioxidants. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1113913
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113913