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Plant-Derived Agents for Counteracting Cisplatin-Induced Nephrotoxicity
Joint Authors
Ojha, Shreesh
Mohanraj, Rajesh
Sadek, Bassem
Venkataraman, Balaji
Kurdi, Amani
Mahgoub, Eglal
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-27, 27 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-27
Country of Publication
Egypt
No. of Pages
27
Main Subjects
Abstract EN
Cisplatin (CSP) is a chemotherapeutic agent commonly used to treat a variety of malignancies.
The major setback with CSP treatment is that its clinical efficacy is compromised by its induction of organ toxicity, particular to the kidneys and ears.
Despite the significant strides that have been made in understanding the mechanisms underlying CSP-induced renal toxicity, advances in developing renoprotective strategies are still lacking.
In addition, the renoprotective approaches described in the literature reveal partial amelioration of CSP-induced renal toxicity, stressing the need to develop potent combinatorial/synergistic agents for the mitigation of renal toxicity.
However, the ideal renoprotective adjuvant should not interfere with the anticancer efficacy of CSP.
In this review, we have discussed the progress made in utilizing plant-derived agents (phytochemicals) to combat CSP-induced nephrotoxicity in preclinical studies.
Furthermore, we have also presented strategies to utilize phytochemicals as prototypes for the development of novel renoprotective agents for counteracting chemotherapy-induced renal damage.
American Psychological Association (APA)
Ojha, Shreesh& Venkataraman, Balaji& Kurdi, Amani& Mahgoub, Eglal& Sadek, Bassem& Mohanraj, Rajesh. 2016. Plant-Derived Agents for Counteracting Cisplatin-Induced Nephrotoxicity. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-27.
https://search.emarefa.net/detail/BIM-1113917
Modern Language Association (MLA)
Ojha, Shreesh…[et al.]. Plant-Derived Agents for Counteracting Cisplatin-Induced Nephrotoxicity. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-27.
https://search.emarefa.net/detail/BIM-1113917
American Medical Association (AMA)
Ojha, Shreesh& Venkataraman, Balaji& Kurdi, Amani& Mahgoub, Eglal& Sadek, Bassem& Mohanraj, Rajesh. Plant-Derived Agents for Counteracting Cisplatin-Induced Nephrotoxicity. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-27.
https://search.emarefa.net/detail/BIM-1113917
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113917