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ROS and ROS-Mediated Cellular Signaling
Joint Authors
Zhang, Jixiang
Wang, Xiaoli
Vikash, Vikash
Ye, Qing
Wu, Dandan
Liu, Yulan
Dong, Weiguo
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-22
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
It has long been recognized that an increase of reactive oxygen species (ROS) can modify the cell-signaling proteins and have functional consequences, which successively mediate pathological processes such as atherosclerosis, diabetes, unchecked growth, neurodegeneration, inflammation, and aging.
While numerous articles have demonstrated the impacts of ROS on various signaling pathways and clarify the mechanism of action of cell-signaling proteins, their influence on the level of intracellular ROS, and their complex interactions among multiple ROS associated signaling pathways, the systemic summary is necessary.
In this review paper, we particularly focus on the pattern of the generation and homeostasis of intracellular ROS, the mechanisms and targets of ROS impacting on cell-signaling proteins (NF-κB, MAPKs, Keap1-Nrf2-ARE, and PI3K-Akt), ion channels and transporters (Ca2+ and mPTP), and modifying protein kinase and Ubiquitination/Proteasome System.
American Psychological Association (APA)
Zhang, Jixiang& Wang, Xiaoli& Vikash, Vikash& Ye, Qing& Wu, Dandan& Liu, Yulan…[et al.]. 2016. ROS and ROS-Mediated Cellular Signaling. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-18.
https://search.emarefa.net/detail/BIM-1113919
Modern Language Association (MLA)
Zhang, Jixiang…[et al.]. ROS and ROS-Mediated Cellular Signaling. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-18.
https://search.emarefa.net/detail/BIM-1113919
American Medical Association (AMA)
Zhang, Jixiang& Wang, Xiaoli& Vikash, Vikash& Ye, Qing& Wu, Dandan& Liu, Yulan…[et al.]. ROS and ROS-Mediated Cellular Signaling. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-18.
https://search.emarefa.net/detail/BIM-1113919
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113919