Aerobic Exercise and Pharmacological Therapies for Skeletal Myopathy in Heart Failure: Similarities and Differences
Joint Authors
Brum, Patricia Chakur
Cunha, Telma F.
Souza, Rodrigo W.
Voltarelli, Vanessa A.
Gabriel-Costa, Daniele
Bacurau, Aline V. N.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-19
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Skeletal myopathy has been identified as a major comorbidity of heart failure (HF) affecting up to 20% of ambulatory patients leading to shortness of breath, early fatigue, and exercise intolerance.
Neurohumoral blockade, through the inhibition of renin angiotensin aldosterone system (RAS) and β-adrenergic receptor blockade (β-blockers), is a mandatory pharmacological therapy of HF since it reduces symptoms, mortality, and sudden death.
However, the effect of these drugs on skeletal myopathy needs to be clarified, since exercise intolerance remains in HF patients optimized with β-blockers and inhibitors of RAS.
Aerobic exercise training (AET) is efficient in counteracting skeletal myopathy and in improving functional capacity and quality of life.
Indeed, AET has beneficial effects on failing heart itself despite being of less magnitude compared with neurohumoral blockade.
In this way, AET should be implemented in the care standards, together with pharmacological therapies.
Since both neurohumoral inhibition and AET have a direct and/or indirect impact on skeletal muscle, this review aims to provide an overview of the isolated effects of these therapeutic approaches in counteracting skeletal myopathy in HF.
The similarities and dissimilarities of neurohumoral inhibition and AET therapies are also discussed to identify potential advantageous effects of these combined therapies for treating HF.
American Psychological Association (APA)
Bacurau, Aline V. N.& Cunha, Telma F.& Souza, Rodrigo W.& Voltarelli, Vanessa A.& Gabriel-Costa, Daniele& Brum, Patricia Chakur. 2016. Aerobic Exercise and Pharmacological Therapies for Skeletal Myopathy in Heart Failure: Similarities and Differences. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1113920
Modern Language Association (MLA)
Bacurau, Aline V. N.…[et al.]. Aerobic Exercise and Pharmacological Therapies for Skeletal Myopathy in Heart Failure: Similarities and Differences. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-16.
https://search.emarefa.net/detail/BIM-1113920
American Medical Association (AMA)
Bacurau, Aline V. N.& Cunha, Telma F.& Souza, Rodrigo W.& Voltarelli, Vanessa A.& Gabriel-Costa, Daniele& Brum, Patricia Chakur. Aerobic Exercise and Pharmacological Therapies for Skeletal Myopathy in Heart Failure: Similarities and Differences. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1113920
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113920