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Monoamine Oxidase Is Overactivated in Left and Right Ventricles from Ischemic Hearts: An Intriguing Therapeutic Target
Joint Authors
Manni, Maria Elena
Rigacci, Stefania
Borchi, Elisabetta
Bargelli, Valentina
Miceli, Caterina
Giordano, Carla
Raimondi, Laura
Nediani, Chiara
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-01
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Growing evidence indicates that reactive oxygen species (ROS) may play a key role in human heart failure (HF).
Monoamine oxidase (MAO) is emerging as a major ROS source in several cardiomyopathies.
However, little is known about MAO activity in human failing heart and its relationship with redox imbalance.
Therefore, we measured MAO activity in the left (LV) and in the right (RV) ventricle of human nonfailing (NF) and in end-stage ischemic (IHD) and nonischemic failing hearts.
We found that both MAO isoforms (MAO-A/B) significantly increased in terms of activity and expression levels only in IHD ventricles.
Catalase and aldehyde dehydrogenase-2 activities (ALDH-2), both implicated in MAO-catalyzed catecholamine catabolism, were significantly elevated in the failing LV, whereas, in the RV, statistical significance was observed only for ALDH-2.
Oxidative stress markers levels were significantly increased only in the failing RV.
Actin oxidation was significantly elevated in both failing ventricles and related to MAO-A activity and to functional parameters.
These data suggest a close association between MAO-A-dependent ROS generation, actin oxidation, and ventricular dysfunction.
This latter finding points to a possible pathogenic role of MAO-A in human myocardial failure supporting the idea that MAO-A could be a new therapeutic target in HF.
American Psychological Association (APA)
Manni, Maria Elena& Rigacci, Stefania& Borchi, Elisabetta& Bargelli, Valentina& Miceli, Caterina& Giordano, Carla…[et al.]. 2016. Monoamine Oxidase Is Overactivated in Left and Right Ventricles from Ischemic Hearts: An Intriguing Therapeutic Target. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113921
Modern Language Association (MLA)
Manni, Maria Elena…[et al.]. Monoamine Oxidase Is Overactivated in Left and Right Ventricles from Ischemic Hearts: An Intriguing Therapeutic Target. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1113921
American Medical Association (AMA)
Manni, Maria Elena& Rigacci, Stefania& Borchi, Elisabetta& Bargelli, Valentina& Miceli, Caterina& Giordano, Carla…[et al.]. Monoamine Oxidase Is Overactivated in Left and Right Ventricles from Ischemic Hearts: An Intriguing Therapeutic Target. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113921
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113921