Targeting Pin1 Protects Mouse Cardiomyocytes from High-Dose Alcohol-Induced Apoptosis
Joint Authors
Yang, Wei
Shan, Lina
Wang, Yuehong
Li, Zizhuo
Zhang, Yu
Sun, Jiantao
Li, Weimin
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-01
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Long-term heavy alcohol consumption is considered to be one of the main causes of left ventricular dysfunction in alcoholic cardiomyopathy (ACM).
As previously suggested, high-dose alcohol induces oxidation stress and apoptosis of cardiomyocytes.
However, the underlying mechanisms are yet to be elucidated.
In this study, we found that high-dose alcohol treatment stimulated expression and activity of Pin1 in mouse primary cardiomyocytes.
While siRNA-mediated knockdown of Pin1 suppressed alcohol-induced mouse cardiomyocyte apoptosis, overexpression of Pin1 further upregulated the numbers of apoptotic mouse cardiomyocytes.
We further demonstrated that Pin1 promotes mitochondria oxidative stress and loss of mitochondrial membrane potential but suppresses endothelial nitric oxide synthase (eNOS) expression in the presence of alcohol.
Taken together, our results revealed a pivotal role of Pin1 in regulation of alcohol-induced mouse cardiomyocytes apoptosis by promoting reactive oxygen species (ROS) accumulation and repressing eNOS expression, which could be potential therapeutic targets for ACM.
American Psychological Association (APA)
Wang, Yuehong& Li, Zizhuo& Zhang, Yu& Yang, Wei& Sun, Jiantao& Shan, Lina…[et al.]. 2015. Targeting Pin1 Protects Mouse Cardiomyocytes from High-Dose Alcohol-Induced Apoptosis. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113926
Modern Language Association (MLA)
Wang, Yuehong…[et al.]. Targeting Pin1 Protects Mouse Cardiomyocytes from High-Dose Alcohol-Induced Apoptosis. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1113926
American Medical Association (AMA)
Wang, Yuehong& Li, Zizhuo& Zhang, Yu& Yang, Wei& Sun, Jiantao& Shan, Lina…[et al.]. Targeting Pin1 Protects Mouse Cardiomyocytes from High-Dose Alcohol-Induced Apoptosis. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113926
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113926